… , using BV2 microglial cell line and primary microglial culture, we … anti-inflammatory effects
of genistein were investigated in LPS-induced microglial activation in murine BV2 microglial …

… Our studies have suggested that GPER expressed on microglia mediated the anti-inflammatory
effect of estradiol after ischemic stroke. Our studies could potentially help to develop …

… siRNA knockdown of GPER inhibited the anti-inflammatory effects of Rg1. Taken together, …
in the anti-inflammatory effects of Rg1 against LPS-induced microglia activation. These …

… Recent studies from our lab have shown that E2 can exert anti-inflammatory effects to
suppress activation of the nod-like receptor protein 3 (NLRP3) inflammasome pathway in the …

… cell line culture, we studied the mechanism for the anti-inflammatory effect of estrogen.
We found that pretreatment with E2, but not co-treatment or post-treatment, inhibited LPS-induced …

… through its potent anti-inflammatory effects in microglial cells. E 2 treatment transforms … /or
aging-dependent changes in microglial activation profiles may be responsible for the observed …

… GPER agonist G1 to prevent inflammatory microglial activation in vivo (46–48… anti-inflammatory
effects of estrogen in cerebral ischaemia (49). These anti-inflammatory effects of estrogen …

… ) is primarily expressed in microglia and mediates microglial activation [10]. The … microglial
activation, further confirming that GPR30 also mediates the anti-inflammatory effect of estrogen…

… Blocking of Ser216 phosphorylation aggravated microglia activation and inflammation of
mouse brain, thus confirming that phosphorylated ERα exerts anti-inflammatory functions. ERα …

… Our data showed that 17β-estradiol inhibited microglia activation in the dorsal horn of L4-L5
lumbar spinal cord developed neuropathic pain after SCI (Fig. 2A). Furthermore, the …