Involvement of spinal cannabinoid CB2 receptors in exercise-induced antinociception

RS Dos Santos, CA Sorgi, APF Peti, FP Veras… - Neuroscience, 2019 - Elsevier
activation of spinal cannabinoid CB 2 receptors and reduction of activated microglia are
involved in exercise-induced antinociception… that the antinociceptive effect induced by exercise …

[HTML][HTML] Effects of cannabinoid type 2 receptor agonist AM1241 on morphine-induced antinociception, acute and chronic tolerance, and dependence in mice

M Zhang, L Dong, H Zou, J Li, Q Li, G Wang, H Li - The Journal of Pain, 2018 - Elsevier
… And the peripheral and spinal antinociceptive effects of … We also tested the effect of a CB 2
agonist on the antinociceptive effect of … We observed that activation of CB 2 receptors not only …

Involvement of spinal cannabinoid receptors in the antipruritic effects of WIN 55,212‐2, a cannabinoid receptor agonist

KA Bilir, G Anli, E Ozkan, O Gunduz… - Clinical and …, 2018 - academic.oup.com
… are known to exert antinociceptive effects. Moreover, both … cannabinoid receptor agonists
attenuate serotonin‐induced … that activation of spinal cannabinoid CB1 receptors may be …

Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain

MB Yuill, DE Hale, J Guindon, DJ Morgan - Molecular pain, 2017 - journals.sagepub.com
… Physical dependence was induced using a series of 20 injections that were given twice …
of markers for microglial and astrocyte activation in the spinal cord that are associated with …

… sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of …

LM Carey, Z Xu, G Rajic, A Makriyannis… - Pharmacological …, 2023 - Elsevier
Cannabinoid type 2 receptor (CB2) agonists alleviate … cell types governing the antinociceptive
effects of CB2 receptor … of a battery of genes in lumbar spinal cords derived from C57BlJ/6 …

Antinociception mechanisms of action of cannabinoid-based medicine: an overview for anesthesiologists and pain physicians

S Narouze - Regional Anesthesia & Pain Medicine, 2021 - rapm.bmj.com
… travels retrograde to stimulate cannabinoids receptors on … to tolerance and antinociceptive
effects of cannabinoids. This … antinociceptive effects via spinal 5-HT7, 5-HT2A and alpha-2

[HTML][HTML] The effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats

S Jahanabadi, MR Hadian, J Shamsaee… - Iranian journal of …, 2016 - ncbi.nlm.nih.gov
… the effect of a high-affinity cannabinoid receptors agonist, … direct actions in the spinal dorsal
horn of nociceptive pathway. … 55, 212-2 produced dose-dependent antinociceptive effects in …

Cannabinoids and pain: sites and mechanisms of action

K Starowicz, DP Finn - Advances in Pharmacology, 2017 - Elsevier
… and synthetic cannabinoid receptor agonists have antinociceptive effects in animal … CB 1 R
and CB 2 R located at peripheral, spinal, or supraspinal sites are … cannabinoid receptor type 2

Spinal cannabinoid CB1 or CB2 receptors activation attenuates mechanical allodynia in streptozotocin-induced diabetic rats

MR Gonçalves, MS da Conceição… - Behavioural …, 2022 - journals.lww.com
… with high cannabinoid receptors expression. Then, this study aimed to evaluate the
potential antinociceptive effect of highly selective cannabinoid receptor agonists, N-(2-chloroethyl)-5Z…

[HTML][HTML] Cannabinoid type 2 receptor system modulates paclitaxel-induced microglial dysregulation and central sensitization in rats

J Wu, M Hocevar, B Bie, JF Foss, M Naguib - The Journal of Pain, 2019 - Elsevier
cannabinoid type 2 (CB2) agonist. We tested the hypothesis that activation of CB2 receptor
… -10) in the spinal cord, which coincided with an antinociception behavior in rats with chronic …