The pleiotropic functions of reactive oxygen species in cancer

K Wu, AE El Zowalaty, VI Sayin… - Nature Cancer, 2024 - nature.com
cells maintain a steady-state redox balance via robust upregulation of cellular antioxidant
well-tolerated GCL inhibitor used to treat recurrent neuroblastoma 159 and multiple myeloma …

[HTML][HTML] Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation

A Ugun-Klusek, TS Theodosi, JC Fitzgerald, F Burté… - Redox Biology, 2019 - Elsevier
… deamination and contribute to reactive oxygen species (ROS) generation … In neuronal cells,
ETC complex inhibition and other stressors … Steady state levels of autophagy substrate p62 (…

[HTML][HTML] Olive Oil Components as Novel Antioxidants in Neuroblastoma Treatment: Exploring the Therapeutic Potential of Oleuropein and Hydroxytyrosol

M Gonçalves, A Aiello, M Rodríguez-Pérez, G Accardi… - Nutrients, 2024 - mdpi.com
cells produce increased amounts of reactive oxygen species, this review highlights the
antioxidant … These polyphenols might inhibit cell proliferation in a concentration-dependent …

… overload, mitochondrial damage and cell death due to toxically high doses of dexamethasone-induced oxidative stress in human neuroblastoma SH-SY5Y cells

W Suwanjang, AY Abramov, K Charngkaew… - Neurochemistry …, 2016 - Elsevier
… levels lead to increases in reactive oxygen species (ROS) … for 40 min or until a steady state
had been reached before images … inhibitor NDGA (10 μM) and xanthine oxidase inhibitor

The antioxidants esculetin and quercetin modulate differently redox balance in human NB4 leukemia cells

V Rubio, AI Garcia-Perez, A Herraez, L Puebla… - bioRxiv, 2024 - biorxiv.org
cell line has increased reactive oxygen species (ROS) levels. Esculetin and quercetin are
antioxidants that alter redox equilibrium, diminishing cellcell lines, esculetin inhibits cell cycle

[HTML][HTML] Hydroxybenzoic acid derivatives as dual-target ligands: mitochondriotropic antioxidants and cholinesterase inhibitors

C Oliveira, F Cagide, J Teixeira, R Amorim… - Frontiers in …, 2018 - frontiersin.org
… observed in differentiated human neuroblastoma (SH-SY5Y) … , high level of potent reactive
oxygen species (ROS), and … , which is the ratio of the steady-state concentrations of the drug in …

[HTML][HTML] Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells

DR Vaddi, L Piao, SA Khan, N Wang, NR Prabhakar… - PloS one, 2019 - journals.plos.org
… In contrast, 2 and 4 days of CH increased the steady state … We previously reported that
reactive oxygen species (ROS) … channels reduce cell proliferation of neuroblastoma cells [16, …

Reactive oxygen species–mediated synergism of fenretinide and romidepsin in preclinical models of T-cell lymphoid malignancies

MR Makena, B Koneru, TH Nguyen, MH Kang… - Molecular cancer …, 2017 - AACR
… 23), while (due to dosing limitations with mice) the maximum steady state plasma … in
neuroblastoma preclinical models between fenretinide and the microtubule inhibitor ABT-…

[HTML][HTML] The medium-chain fatty acid decanoic acid reduces oxidative stress levels in neuroblastoma cells

J Mett, U Müller - Scientific Reports, 2021 - nature.com
… elevated levels of reactive oxygen and nitrogen species (ROS… the medium and to inhibit cell
proliferation, the concentration … and Neuro2a cells resulting in a declined steady state level …

Crosstalk between calcium and reactive oxygen species signaling in cancer

N Hempel, M Trebak - Cell calcium, 2017 - Elsevier
… The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …