Old drugs for a new virus: repurposed approaches for combating COVID-19

S Saul, S Einav - ACS infectious diseases, 2020 - ACS Publications
… The development of novel antiviral drugs is expensive and … chemically distinct nucleoside
and nucleotide analogues that … with a great potential to be repurposed into antivirals. Beyond …

Repurposing nucleoside analogs for human coronaviruses

K Zandi, F Amblard, K Musall… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
… of compounds and identified novel nucleoside analogs with antiviral activity against CoV-2 …
and experimental antiviral nucleoside analogs for their potential in vitro antiviral activity …

[HTML][HTML] Drug repurposing for COVID-19: A review and a novel strategy to identify new targets and potential drug candidates

L Rodrigues, R Bento Cunha, T Vassilevskaia… - Molecules, 2022 - mdpi.com
… tested until now, including antiviral and antiparasitic drugs, steroids, signalling inhibitors, …
that acts as adenosine ribonucleotide triphosphate analogue. It was shown to inhibit the activity …

Drug repurposing for new, efficient, broad spectrum antivirals

M García-Serradilla, C Risco, B Pacheco - Virus research, 2019 - Elsevier
… acidic organelles at some point of their replication cycle. This has prompted the study of
CQ and its hydroxyl analogue hydroxychloroquine (HCQ) as potential antiviral drugs. CQ and …

Evaluation of acridinedione analogs as potential SARS-CoV-2 main protease inhibitors and their comparison with repurposed anti-viral drugs

VK Bhardwaj, R Singh, P Das, R Purohit - … in Biology and Medicine, 2021 - Elsevier
… In the present study, acridinedione based analogs have been prioritized over repurposed
anti-viral drugs. The selected DSPD molecules 2 and 6 showed better interaction energy with …

[HTML][HTML] Drug repurposing approaches to combating viral infections

J Trivedi, M Mohan, SN Byrareddy - Journal of clinical medicine, 2020 - mdpi.com
… as antiviral molecules, the drug repurposing approach is … RTIs are nucleotide analogs, which
hamper cellular DNA … ritonavir demonstrated significant anti-viral potential against SARS as …

[HTML][HTML] SARS-CoV-2: repurposed drugs and novel therapeutic approaches—insights into chemical structure—biological activity and toxicological screening

CA Dehelean, V Lazureanu, D Coricovac… - … of clinical medicine, 2020 - mdpi.com
… of various nucleoside analogues used as antivirals [59]. … structure of the virus was elucidated,
leading to the development of diagnostic tools and of potential novel innovative antivirals; (…

[HTML][HTML] Putative repurposing of lamivudine, a nucleoside/nucleotide analogue and antiretroviral to improve the outcome of cancer and COVID-19 patients

JJ García-Trejo, R Ortega, M Zarco-Zavala - Frontiers in Oncology, 2021 - frontiersin.org
… The antivirals most frequently used for HIV, HBV and HCV infections are shown in Table
1 … C infection, gained attention due to their potential effectiveness against the SARS-CoV-2 …

Repurposing approved drugs as potential inhibitors of 3CL-protease of SARS-CoV-2: Virtual screening and structure based drug design

FJ Meyer-Almes - Computational Biology and Chemistry, 2020 - Elsevier
… , a broad-spectrum antiviral agent that was previously tested in … B) 6-Methylaminoethyl-analog
of oxytetracycline with an … Besides known substance classes like flavonoids several novel

[HTML][HTML] Drug repurposing strategy (DRS): Emerging approach to identify potential therapeutics for treatment of novel coronavirus infection

BM Sahoo, BVV Ravi Kumar, J Sruti… - Frontiers in Molecular …, 2021 - frontiersin.org
… Remdesivir is a novel nucleotide analogue that inhibits viral RNA polymerases and used
as broad-spectrum antiviral drug (Eastman, 2020). Similarly, favipiravir (T-705) is a synthetic …