… ameliorate pain and anxiety compared to placebo in wisdom … of selective MT2 receptor partial
agonists (UCM765 and UCM924) [164… Notably, MT2 partial agonists also display anxiolytic …

… the effects of the selective MT 2 receptor partial agonist N-{2-[(… ) [41], the selective MT 1
receptor partial agonist N-(2-{Methyl-[… The effect of vehicle was compared with that of the different …

… toward a partial agonism for the phenyl derivative UCM765 or … activity of UCM765 in this
animal model, compared to that of … UCM765 also exhibited anxiolytic activity in different rat …

… compared the 3D structural model of the MT 1 receptor in inactive form to the active
UCM871-bound MT 1, revealing that the largest structural difference, … MT 1 receptors partial …

… across the whole 24 hours in MT 2 −/− mice compared with MT 2 +/+ mice. Importantly, the
… the anxiolytic effects of the MT 2 partial agonist UCM765 and of MLT through MT 2 receptors …

… of a novel selective melatonin MT 2 receptor partial agonist N-{… antinociceptive effect was
produced by 20 mg/kg of UCM765 … On the other hand, the anxiolytic effect of melatonin leads to …

… agonists are compared with regard to half-life, receptor affinity, … , MA-2, tasimelteon,
UCM765, and UCM924. Apart from … Anxiolytic properties have been ascribed to melatonin and …

… and MT2 receptor, and the MT2 upstream position in the descending pathway compared to
MOR … These findings suggest a safe profile for MT2 partial agonists regarding their potential …

… effects, and a partial agonism at the serotonin 1A receptor, … Melatonin’s anxiolytic effects
might be associated with direct … The selective stimulation of MT2 receptors by UCM765 …

… melatonin receptor agonists have a long half-life, high absorption rate, and more obvious
curative effects compared with melatonin … exert antidepressant and anti-anxiety effects in rodent …