Eukaryotic DNA polymerases
M Fry - Enzymes of nucleic acid synthesis and modification, 2018 - taylorfrancis.com
… B y clear contrast, aphidicolin does not inhibit activities of fl … -a showed that although
aphidicolin did not affect the polymerization of … of calf thymus p-polymerase, Escherichia coli DNA …
aphidicolin did not affect the polymerization of … of calf thymus p-polymerase, Escherichia coli DNA …
[HTML][HTML] DDK has a primary role in processing stalled replication forks to initiate downstream checkpoint signaling
… with the ssDNA exonuclease EXO1 and phosphorylates … , aphidicolin treatment, which
inhibits DNA polymerase alpha … -mediated nucleolytic resection of newly synthesized DNA as …
inhibits DNA polymerase alpha … -mediated nucleolytic resection of newly synthesized DNA as …
Studies on DNA-related enzymes to elucidate molecular mechanisms underlying genetic information processing and their application in genetic engineering
Y Ishino - Bioscience, Biotechnology, and Biochemistry, 2020 - academic.oup.com
… ligase, from the Escherichia coli genome. … To use T7 DNA polymerase, its strong 3′-5′
exonuclease activity had … DNA (DNA strand synthesis) were inhibited by aphidicolin (a specific …
exonuclease activity had … DNA (DNA strand synthesis) were inhibited by aphidicolin (a specific …
TREX1 degrades the 3′ end of the small DNA oligonucleotide products of nucleotide excision repair in human cells
SH Kim, GH Kim, MG Kemp, JH Choi - Nucleic Acids Research, 2022 - academic.oup.com
… inhibit TREX1 nucleolytic activity. We therefore exposed a 5′-biotinylated 30-mer DNA …
S4), which like TREX1 has 3′ exonuclease activity that is inhibited by the presence of UV …
S4), which like TREX1 has 3′ exonuclease activity that is inhibited by the presence of UV …
The SOS and RpoS regulons contribute to bacterial cell robustness to genotoxic stress by synergistically regulating DNA polymerase Pol II
… in Escherichia coli is a coordinated cellular response to DNA damage that involves at least
… Therefore, we showed that RpoS positively regulates the expression of polB, but not of the …
… Therefore, we showed that RpoS positively regulates the expression of polB, but not of the …
Human Endonuclease ANKLE1 Localizes at the Midbody and Processes Chromatin Bridges to Prevent DNA Damage and cGAS‐STING Activation
H Jiang, N Kong, Z Liu, SC West… - Advanced Science, 2023 - Wiley Online Library
… cells is rescued by inhibiting actin polymerization or reducing … Aurora B activity, we treated
cells with an Aurora B inhibitor, … of ICRF-193, but not to cytotoxic agents such as aphidicolin, …
cells with an Aurora B inhibitor, … of ICRF-193, but not to cytotoxic agents such as aphidicolin, …
[HTML][HTML] Mechanisms of direct replication restart at stressed replisomes
BA Conti, A Smogorzewska - DNA repair, 2020 - ncbi.nlm.nih.gov
… pools by inhibiting ribonucleotide reductase [7–9], aphidicolin, … in studies from Escherichia
coli that found an accumulation of … This model also predicts that 5’–3’ nucleolytic resection is …
coli that found an accumulation of … This model also predicts that 5’–3’ nucleolytic resection is …
The fragility of a structurally diverse duplication block triggers recurrent genomic amplification
R Suzuki, MM Murata, N Manguso… - Nucleic Acids …, 2021 - academic.oup.com
… The exonuclease activity of DNA repair protein Mre11 … With the mild inhibition of DNA
replication by aphidicolin and … Simple organisms such as Escherichia coli and Saccharomyces …
replication by aphidicolin and … Simple organisms such as Escherichia coli and Saccharomyces …
DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells
… We report that it inhibits resection by directly interacting with … helicase (Blm) after aphidicolin
treatment 32 . Following up on … further, we adopted the Escherichia coli LacI/LacO tethering …
treatment 32 . Following up on … further, we adopted the Escherichia coli LacI/LacO tethering …
The structure and mechanism of the EXD2 nuclease in DNA repair
K Chabowska - 2023 - repository.icr.ac.uk
… non-canonical DNA structures, facilitating DNA replication. Moreover, RPA inhibits EXD2
activity on … ) mutant, exhibits 3’-5’ exonuclease activity on mismatched DNA but not on abasic …
activity on … ) mutant, exhibits 3’-5’ exonuclease activity on mismatched DNA but not on abasic …