Effects of the oral, direct factor Xa inhibitor edoxaban on routine coagulation assays, lupus anticoagulant and anti-Xa assays

A Hillarp, K Strandberg, F Baghaei… - … Journal of Clinical …, 2018 - Taylor & Francis
… , the in vitro effects of edoxaban were more similar to rivaroxaban than apixaban. For
measurement of edoxaban concentration in plasma, it is possible to use the chromogenic …

[HTML][HTML] A diagnostic solution for lupus anticoagulant testing in patients taking direct oral FXa inhibitors using DOAC filter

C Farkh, S Ellouze, L Gounelle, M Sad Houari… - Frontiers in …, 2021 - frontiersin.org
… Background: Direct oral factor Xa (FXa) inhibitors interfere with … We evaluated a new device,
called DOAC Filter, and its … patients receiving direct oral FXa inhibitors (41 apixaban and 38 …

Apixaban to prevent stroke in patients with atrial fibrillation: a review

BE Peterson, SM Al-Khatib… - Therapeutic Advances …, 2017 - journals.sagepub.com
oral anticoagulants with direct factor IIa or factor Xa inhibition has … apixaban and tackles the
generalizability of the findings with … the emerging evidence supporting the use of apixaban to …

[HTML][HTML] New direct oral anticoagulants (DOAC) and their use today

H Schwarb, DA Tsakiris - Dentistry journal, 2016 - mdpi.com
factor Xa inhibitors is the inhibition of prothrombinase complex-bound and clot-associated
factor Xa, … Apixaban is another highly selective and reversible inhibitor of free and clot-bound …

Reversing factor Xa inhibitors–clinical utility of andexanet alfa

S Kaatz, H Bhansali, J Gibbs, R Lavender… - Journal of blood …, 2017 - Taylor & Francis
… Citation6 For the oral direct thrombin inhibitor, dabigatran, a … For oral direct factor Xa (FXa)
inhibitors, including apixaban, … alfa, a new investigational drug that binds to FXa inhibitors and …

Comparison of high-and low-dose 4-factor prothrombin complex concentrate for the emergent reversal of oral factor Xa inhibitors

M Hormese, A Littler, B Doane, N Glowacki… - Journal of thrombosis …, 2021 - Springer
… anticoagulants are warfarin and oral Factor Xa inhibitors such as rivaroxaban (Xarelto®)
and apixaban (Eliquis®). The increasing use of oral Factor Xa inhibitors has coincided with an …

Laboratory measurement of apixaban using anti-factor Xa assays in acute ischemic stroke patients with non-valvular atrial fibrillation

H Shin, MC Cho, RB Kim, CH Kim, NC Choi… - Journal of Thrombosis …, 2018 - Springer
… Of the factor Xa inhibitors, apixaban has the favorable profile in terms of bleeding risk, which
… lag behind new drug development, specifically regarding factor Xa inhibitors. Knowing the …

Nonhemostatic activities of factor Xa: are there pleiotropic effects of anti-FXa direct oral anticoagulants?

S Papadaki, AD Tselepis - Angiology, 2019 - journals.sagepub.com
oral anticoagulants (DOACs) targeting FXa have been developed. Rivaroxaban, apixaban,
… -1 and PAR-2, respectively, resulting in the new N-termini S 42 FLLRN 47 and S 37 LIGKV …

The direct oral anticoagulants apixaban, rivaroxaban, and edoxaban

KA DeHaas - American Society for Clinical Laboratory Science, 2017 - clsjournal.ascls.org
Apixaban is a direct factor Xa inhibitor. It does not require antithrombin for antithrombotic
activity. Apixaban inhibits free and clot-bound factor Xa … unfamiliarity with this new method but …

Reversing the effect of oral anticoagulant drugs: established and newer options

JE Ansell - American Journal of Cardiovascular Drugs, 2016 - Springer
… In the last decade, a new class of oral anticoagulants has … oral direct factor Xa inhibitors
as well as the indirect inhibitor … IIa and Xa inhibitors (dabigatran, rivaroxaban, apixaban and …