[HTML][HTML] Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
… In a tentative exploration of hospital-treated sepsis data obtained from high-income … via
suppressing myocardial and serum inflammatory cytokines, apoptosis, and pyroptosis. STING-…

[HTML][HTML] Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis

C Cao, M Yu, Y Chai - Cell death & disease, 2019 - nature.com
… to apoptosis in sepsis, thus potentially serving as targetsapoptosis could be a new
therapeutic approach in sepsis. Further, exploring potential therapeutic targets related to apoptosis

The pathogenesis and potential therapeutic targets in sepsis

W Zhang, H Jiang, G Wu, P Huang, H Wang, H An… - MedComm, 2023 - Wiley Online Library
apoptosis in mice during sepsis, suggesting that the ER stress-mediated apoptosis pathway
may be a new target … basis for further exploration of the treatment of sepsis. Here, we review …

[HTML][HTML] Ferroptosis in sepsis: the mechanism, the role and the therapeutic potential

L Xl, Z Gy, CN - Frontiers in Immunology, 2022 - frontiersin.org
… Ferroptosis is an iron-dependent, non-apoptotic cell death … , etc., and finding potential targets
may offer new prospects for the … In conclusion, the process of exploring the mechanism of …

[HTML][HTML] Potential therapy strategy: targeting mitochondrial dysfunction in sepsis

H Zhang, Y Feng, Y Yao - Military Medical Research, 2018 - Springer
… first observed high rates of apoptosis in splenic lymphocytes and other organs after sepsis,
and inhibition of apoptosis with caspase inhibitors improves survival in sepsis [66, 67]. To …

[HTML][HTML] Long noncoding RNAs: A potential target in sepsis-induced cellular disorder

F Lu, Y Hong, L Liu, N Wei, Y Lin, J He… - Experimental Cell …, 2021 - Elsevier
… inflammatory factor release and T lymphocyte apoptosis in sepsis [61]. As technology …
Since sepsis is defined as organ failure, to further explore the therapeutic targets of lncRNAs…

The potential immunological mechanisms of sepsis

X Zhang, Y Zhang, S Yuan, J Zhang - Frontiers in Immunology, 2024 - frontiersin.org
… -depth exploration of the critical mechanisms underlying sepsis, … DCs could be a promising
therapeutic target for sepsis (41). … apoptosis has been demonstrated to lower sepsis mortality (…

The immunopathology of sepsis and potential therapeutic targets

T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
… -induced inflammation, they also have dysfunctional features that impair their antimicrobial
capacities; key findings in sepsis are the delayed apoptosis of neutrophils and the …

Therapeutic potential of extracellular vesicles for sepsis treatment

SM Kronstadt, AE Pottash, D Levy, S Wang… - … therapeutics, 2021 - Wiley Online Library
… One such new direction has been the exploration of cell-… [ 43 ] Splenocyte apoptosis in
murine sepsis was also shown to … as a viable therapeutic target for sepsis with the demonstrated …

[HTML][HTML] Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management

C Song, J Xu, C Gao, W Zhang, X Fang… - Frontiers in …, 2022 - frontiersin.org
exploring macrophage-based nano-management in sepsis. … In addition, pathogens induce
macrophage apoptosis, pyroptosis, … to achieve macrophage-targeted therapy in sepsis. …