… pro-apoptotic CHOP[32,33]. Increased CHOP is found to be protective in a severe AP animal
… injured acinar cells toward less harmful apoptosis instead of more destructive necrosis[31]. …

… the apoptosis of pancreatic acinar cells in an experimental model of acute pancreatitis was
… death: the “good” (environment-friendly) and the “bad” (environment-spoiling), respectively, …

… is whether the defensive mechanism of the pancreas such as autophagy 13 and endosomal/…
from an isolated episode of acute pancreatitis to chronic pancreatitis 15 with atrophy, …

… , and such upregulation was correlated positively with acinar cell apoptosis and protection
against acinar cell necrosis. Furthermore, high dose of aspirin group showed better protective …

… Our results suggest that pioglitazone promotes apoptosis of pancreatic acinar cells during
AP via activation of caspases, which may involve both intrinsic and extrinsic apoptotic …

… perturbation in the pancreatic acinar cells. For decades, the … the intra-acinar events in acute
pancreatitis. Recent advances … in the acinar cells promotes apoptosis, a less severe form of …

… Pancreatic acinar cell death is the major pathophysiological change in early acute pancreatitis
… life-threatening disease with a poor prognosis. The clinical treatment for AP experiences …

… acinar cells in the early stages of acute pancreatitis. Representative transmission electron
micrographs of pancreatic acinar cells … with apoptosis.7, 36 Necrosis is associated with poor …

… Treatment of acute pancreatitis (AP) and chronic pancreatitis (CP) … pancreatic acinar
cell apoptosis in a mouse model of pancreatitis 14 , we examined the expression of apoptotic …

… in acinar cells is a central event in acute pancreatitis that mediates pro-… cellular responses,
apoptosis ensues 87 . Given the heavy protein production of acinar cells, the pancreas is …