The combination of alcohol and cigarette smoke induces endoplasmic reticulum stress and cell death in pancreatic acinar cells

A Lugea, A Gerloff, HY Su, Z Xu, A Go, C Hu… - Gastroenterology, 2017 - Elsevier
… death (necrosis + apoptosis) in pancreas from ALS, as compared with the AS and AL groups
(… Interestingly, acinar cell apoptosis was increased in the AS group, in the absence of LPS-…

[HTML][HTML] The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis

X Zhou, L Xie, F Bergmann, V Endris, O Strobel… - Cell death …, 2017 - nature.com
… ) can induce acinar cell death, thereby triggering acute pancreatitis (AP) and later chronic …
which are known to promote acinar cell apoptosis and necrosis in pancreatitis. In humans, the …

Research progress on the relationship between acute pancreatitis and calcium overload in acinar cells

S Feng, Q Wei, Q Hu, X Huang, X Zhou, G Luo… - Digestive Diseases and …, 2019 - Springer
Severe acute pancreatitis is characterized … cell death through both necrosis and apoptosis
[3]. More than 20 years ago, since the discovery of calcium overload of pancreatic acinar cells (…

[HTML][HTML] Tricetin reduces inflammation and acinar cell injury in cerulein-induced acute pancreatitis: the role of oxidative stress-induced DNA damage signaling

M Nagy-Pénzes, Z Hajnády, Z Regdon, MÁ Demény… - Biomedicines, 2022 - mdpi.com
acinar cells is the most studied cause of pancreatitis and the focus of our studies is also on
these cells… Tricetin inhibits tissue injury, edema, apoptosis, and necrosis in acute pancreatitis. …

[HTML][HTML] Pathogenic mechanisms of pancreatitis

M Manohar, AK Verma, SU Venkateshaiah… - World journal of …, 2017 - ncbi.nlm.nih.gov
… STAT-3 activation in the pancreatic acinar cells and consequently diminishes the severity
of acute pancreatitis by induction of pancreatic acinar cell apoptosis[26]. Apart from this, …

[HTML][HTML] Murine models of acute pancreatitis: a critical appraisal of clinical relevance

P Silva-Vaz, AM Abrantes, M Castelo-Branco… - International journal of …, 2019 - mdpi.com
… such as interstitial edema, acinar cell death, parenchymal loss, hemorrhage, inflammatory …
in rats, the predominant mechanism of cell death is apoptosis. This model may be suitable for …

Characteristics of long noncoding RNAs in the pancreas of rats with acute pancreatitis

S Xia, J Lin, L Wang, X Shuang, R Li, W Zhang… - Pancreas, 2020 - journals.lww.com
pancreatic acinar cells from necrosis during pancreatic inflammatory injury. The Bcl2l1, Atf4,
and Bad … -induced apoptosis. In the cerulein hyperstimulation rat model of experimental …

A novel function of IRF9 in acute pancreatitis by modulating cell apoptosis, proliferation, migration, and suppressing SIRT1-p53

BH Xue, Y Liu, H Chen, Y Sun, WL Yu - Molecular and Cellular …, 2020 - Springer
… of SIRT1 by IRF9 and cell apoptosis in AP. These results in our research first indicated
that IRF9 could modulate cell apoptosis, proliferation, and migration of acinar cells in AP. …

[HTML][HTML] Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity

Y Liu, XD Chen, J Yu, JL Chi, FW Long, HW Yang… - Cell death & …, 2017 - nature.com
cell death and inflammation in acute pancreatitis remains unclear. Our findings demonstrate
that lack of XIAP promotes apoptosis and inhibits necrosis in acinar cells, decreases the …

[HTML][HTML] HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis

Y Lu, B Li, M Wei, Q Zhu, L Gao, N Ma, X Ma… - International …, 2023 - Elsevier
Pancreatic acinar cell injury or death is the initial step and then triggers inflammation and
immune responses. Different from apoptosis … showed poor potency for AP severity evaluation. …