Mechanisms and consequences of cancer genome instability: lessons from genome sequencing studies
… , it is evident that nucleotide-level genomic instability can … by background mutations or
normal replication errors (151). … of cancer-related genes in conjunction with genomic instability …
normal replication errors (151). … of cancer-related genes in conjunction with genomic instability …
WWOX, the FRA16D gene: A target of and a contributor to genomic instability
T Hussain, B Liu, MS Shrock… - Genes …, 2019 - Wiley Online Library
… and stomach cancers, among other malignancies suggesting its function as a tumor suppressor
… linked to cancer-related chromosomal translocations due to the apparent proximity of …
… linked to cancer-related chromosomal translocations due to the apparent proximity of …
Relative telomere length change in colorectal carcinoma and its association with tumor characteristics, gene expression and microsatellite instability
… and selected group of cancer related genes: In light of well-… shortening was more noticeable
in low-grade tumors (which … /F-statistics for the model error) representing the significance of …
in low-grade tumors (which … /F-statistics for the model error) representing the significance of …
Integrating the DNA damage and protein stress responses during cancer development and treatment
… We also discuss potential means to exploit key cancer-related … the relatively unstable
non-template ssDNA of the R-loop can … From all of the above, it is evident that we are moving from …
non-template ssDNA of the R-loop can … From all of the above, it is evident that we are moving from …
Repetitive DNA sequence detection and its role in the human genome
… Furthermore, HERVs and mammalian apparent LTR … effects on nearby genes, including
cancer-related genes 106 (… These unstable repeats are found in up to 20% of eukaryotic genes …
cancer-related genes 106 (… These unstable repeats are found in up to 20% of eukaryotic genes …
[HTML][HTML] Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects
ZQ Han, LN Wen - World Journal of Gastrointestinal Oncology, 2023 - ncbi.nlm.nih.gov
… , G-quadruplex structures have obvious polymorphisms. X-ray … -quadruplex stability may
reduce replication initiation activity … G-quadruplexes of cancer-related genes in cancer cells and …
reduce replication initiation activity … G-quadruplexes of cancer-related genes in cancer cells and …
Automated next-generation profiling of genomic alterations in human cancers
… for examination of 505 cancer-related genes. Independent … tissue complete microsatellite
instability detection approach … To evaluate the limit of blank, or the apparent TMB in samples …
instability detection approach … To evaluate the limit of blank, or the apparent TMB in samples …
DNA methylation profiling of hTERT gene alongside with the telomere performance in gastric adenocarcinoma
S Vahidi, SE Norollahi, S Agah… - Journal of Gastrointestinal …, 2020 - Springer
… impress the gene expression and genomic stability and cause … and miRNA via silencing
cancer-related genes or the control … It is now significantly obvious that TERRA transcripts actively …
cancer-related genes or the control … It is now significantly obvious that TERRA transcripts actively …
Mechanisms of gastrointestinal malignancies
BW Katona, JP Lynch - Physiology of the Gastrointestinal Tract, 2018 - Elsevier
… While it is apparent that certain genetic mechanisms are … genomic instability within multiple
different gastrointestinal cancers… is compromised and sequence errors begin to accumulate in …
different gastrointestinal cancers… is compromised and sequence errors begin to accumulate in …
Unboxing the molecular modalities of mutagens in cancer
… devoted to protect the DNA to ensure genetic stability, any … radiations, DNA replicative errors,
and various endogenous and … Evident studies suggest that ubiquitin E3 ligases such as the …
and various endogenous and … Evident studies suggest that ubiquitin E3 ligases such as the …