… stroke [1]. As a major consequence of stroke, brain edema leads to the swelling of cerebral
… an important role in edema formation and resolution in cerebral vascular disease. Careful …

… The aim of this review is to look into: (1) the role of aquaporin-4 in the development of
cerebral edema; (2) the potential of aquaporin-4 as a therapeutic target in edema with our new …

… target to act on cerebral edema. … on stroke pathophysiology: in rodent stroke models, early
increases in expression of AQP4 parallels the development of ionic brain edema and swelling …

… fluid clearance out of the brain (perivenous spaces) with a key role of aquaporin-4 (AQP4) …
biomarkers predicting risk of cerebrovascular disorder before the clinical onset of ischemic …

… cerebrovascular diseases. This review focuses on expression of AQP4 and the effects of AQP4
on brain edema and neural cells injuries in cerebrovascular … excellent therapeutic target. …

… These findings suggest that the BBB NKCC may be a potential therapeutic target … Aquaporin-4
deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. …

… The aim of this study is to investigate the effect … target for the treatment of brain edema in
cerebral ischaemia-reperfusion, and MCC950 has potential value for ischaemic stroke treatment…

… and memory formation [4], cerebrovascular disease [5,6], … aquaporin channels in the
nervous system might provide many targets for novel therapies for diseases from brain …

… As we know, traumatic brain edema (TBE) is caused by a specific water channel mediated
by membrane aquaporins in cell membranes and by breakdown of the blood–brain barrier (…

… therapeutic window for AQP4-targeted therapy. A related concern is whether AQP4 inhibition,
as might be used to reduce brain edema early in ischemic stroke, might produce seizures …