Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet?

M Verbelen, ME Weale, CM Lewis - The pharmacogenomics journal, 2017 - nature.com
… to be cost-effective, we assumed that PGx-guided treatment … testing strategy cost-effective
(odds ratio=0.13, P-value <0.05). … for 5 of the 10 drugs covered in this review. Similarly, the cost …

On what basis are medical cost-effectiveness thresholds set? Clashing opinions and an absence of data: a systematic review

D Cameron, J Ubels, F Norström - Global health action, 2018 - Taylor & Francis
… regarding the validity of cost-effective ratios and QALYs may … compensation for the medicines
used to treat Pompe disease … Given the high price of this drug, this example demonstrates …

… the challenge of high-priced prescription drugs in the era of precision medicine: A systematic review of drug life cycles, therapeutic drug markets and regulatory …

T Gronde, CA Uyl-de Groot, T Pieters - PloS one, 2017 - journals.plos.org
… [1;47;48] Though the prices of these drugs were much lower than current new drug price
drugs as not cost-effective.[148;151] Also, the evidence for the effectiveness of orphan drugs is …

[HTML][HTML] Systematic review of the evidence on the cost-effectiveness of pharmacogenomics-guided treatment for cardiovascular diseases

Y Zhu, KM Swanson, RL Rojas, Z Wang, JLS Sauver… - … in Medicine, 2020 - Elsevier
… PGx-guided treatment for the drugs clopidogrel and warfarin … PGx-guided clopidogrel
treatment was cost-effective in the … , this study did not specifically examine economic value, but …

A systematic review of economic evaluations of pharmacogenetic testing for prevention of adverse drug reactions

CO Plumpton, D Roberts, M Pirmohamed… - Pharmacoeconomics, 2016 - Springer
… to treatment with a number of common drugs. … review has identified tests that are cost effective,
but analyses should be updated and revisited as the evidence base matures and the price

[HTML][HTML] Economics and cost-effectiveness of multiple sclerosis therapies in the USA

DM Hartung - Neurotherapeutics, 2017 - Elsevier
… The evidence of how restrictive drug policies or increasing out… annual net price of $58,608
to be considered cost-effective. … drugs, and specifically DMTs, are the single largest medical

[PDF][PDF] Economics of innovative payment models compared with single pricing of pharmaceuticals

A Cole, A Towse, P Lorgelly, R Sullivan - London: Office of Health …, 2018 - academia.edu
… Whilst we cannot provide evidence of indications that are not being developed … drugs not
being cost-effective even at zero price, eg when used in combination with other costly therapies

Cost-effectiveness of biological asthma treatments: a systematic review and recommendations for future economic evaluations

RB McQueen, DN Sheehan, MD Whittington… - …, 2018 - Springer
… was cost-effective only when targeted to specific severe subgroups or given considerable
price … Eight were funded by the manufacturer of omalizumab (Novartis Pharmaceuticals Corp.), …

The value of self-medication: summary of existing evidence

J Noone, CM Blanchette - Journal of medical economics, 2018 - Taylor & Francis
… when a class of drugs becomes available without prescription… improved access to cost-effective
treatment without the need … in this review show that the availability of self-care medicines

Value-based pricing for emerging gene therapies: the economic case for a higher cost-effectiveness threshold

LP Garrison, T Jackson, D Paul, M Kenston - Journal of managed care & …, 2019 - jmcp.org
drugs and procedures (Table 1). For example, ICER calculated lifetime cost estimates or
incremental cost-effectivemedical care purchases. These additional elements, we would argue, …