… asthma in AERD typically present during the third or fourth decade of life, which contrasts with
the early childhood onset of CRSwNP and asthma in aspirin… CRS has increasingly clarified …

… of the COX product PGD 2 , this can be readily explained by the superseding influences of
the direct activating effects of aspirin (and other COX inhibitors) on eosinophils and mast cells…

… Increased LTE4 excretion has been demonstrated in allergen-induced asthma, asthma
exacerbations, aspirin challenge, and increased basal excretion in AERD.11, 12, 13, 17, 18, 19 …

… preaspirin desensitization patients reveals a clear difference between controls and predose
… The further the effect size is away from 1, the higher the difference. Effect sizes lower than 1 …

… This has been explained by smaller airway size in boys … with occupational asthma,
aspirin-associated asthma, and asthma … Exercise-induced asthma can be diagnosed in children or …

… Both lipoxin A4 and PGI2 have vasodilator, platelet anti-aggregator and anti-inflammatory …
of aspirin. Paradoxically, other NSAIDs may not have the same actions as that of aspirin on …

… often negative, even in patients with a clear history of FDEIA. … us to exclude exercise-induced
bronchoconstriction. The foods … Furthermore, aspirin induced positive results in 14 patients …

… Size of each box (point estimate of each study) reflects the … study has on the pooled results.
ASPRE indicates Combined Multimarker Screening and Randomized Treatment With Aspirin …

… * %R 2 is the relative proportion of variance explained by a variable, which … is the effect
size; a variable with a relatively large portion of R 2 consistently has a relatively large effect size (…

… More studies are needed to determine the effect size for … of aspirin sensitivity in subjects
with asthma and could be used to identify the risk of aspirin intolerance in subjects with asthma. …