… Being homozygous for the Asp 40 allele of this polymorphism (GG) has been linked with
greater opioid analgesic requirements for pain relief after total knee arthroplasty [8]. …

… of CYP2D6, which is generally most relevant for opioids, currently has a total cost of about …
treatment with opioid analgesics is expected, it is our opinion that CYP genotyping should be …

… The cytochrome P450 2D6 (CYP2D6) genotype is thought to … , but the clinical benefits of
opioid analgesics are dependent … This paper refers to genetic variability in µ-opioid receptors (…

… on opioid analgesia in the acute pain setting has not yet been fully elucidated. Overall, …
variability in morphine pharmacodynamics, we did not find any correlation between genotype/…

… the wide interindividual variability in the analgesic response. … and differences in the opioid
analgesic effect in patients with … Thus, we analyzed the influence of the genotype of the SNPs…

… markers as predictors of response to opioid analgesics. … OPRM1 genotypes (20% for AA vs
21% for AG/GG genotypes… interindividual variation in opioid dose requirements in relation to …

… This combined genotype was not related with pain intensity preconsult (T0d). This could
be due to inadequate analgesia before PCT intervention, as that was the reason the PCT was …

… Notably, there is tremendous interindividual variation in response to opioid analgesia. For …
these genotypes are associated with opioid response in our study. Due to the association with …

… Genetic variability in COMT genotypes has been found to be associated with pain … of
interest, particularly in the context of opioid analgesic responsiveness. There are several genetic …

… correlation with CYP3A4 SNPs. In our meta-analysis, we failed to observe a significant
association between postoperative pain … associated with OPRM1 gene polymorphism genotype …