… More importantly, in the presence of the 5hmC mark, MBD1 cannot bind to the CpG sites,
allowing for an open chromatin structure and increased response of Pomc to energy-storage …

… of 5-mC and 5-hmC at the same hemi-modified CpG dyads … the CRE-regulated promoter are
qualitatively and quantitatively … DNA demethylation in cells, we suggest that generation of 5-…

… As compared to passive demethylation, active demethylation … each of these regulates
chromatin structure: posttranslational … , remodeling complexes alter chromatin organization by …

… in mouse DNA fragments resulted in alterations to 5mC levels, … with the potent demethylating
agent 5-azacytidine (5-aza-C) … , 5-aza-C treatment induced global DNA demethylation and …

… in the process of active DNA demethylation, but is also a key … due to the association between
non-CpG methylation and … Recent studies suggest that altered 5mC or 5 hmC can affect …

… [5,6]). A subset of histone modifications appears to directly regulate chromatin structure by
… Much like histones, DNA can be modified in several ways, most notably by the methylation …

… across different tumor types (2,5–8). Studies on such … -promoter regions, and in line with
our results, associations … Either loss or gain of FoxM function can alter cell fate and promote …

… is linked to abnormal epigenetic alterations such as DNA … chromatin structure and reactivate
silenced genes [12,13], potentially reverting malignancy-associated epigenetic alterations in …

… We also show that silent CpG-rich unmethylated promoters … To generate Circos plots,
association with ChromHMM … promoters silent in BasoEs that changed chromatin structure …

… encroachment across the 5′ or 3′ CpG island borders. … in concordant alterations in
H3K4me1 levels and CpG island border … A bivalent chromatin structure marks key developmental …