Importance Combined use of inhaled corticosteroids and long-acting β-agonists (LABAs) as
the controller and the quick relief therapy termedsingle maintenance and reliever therapy
(SMART) is a potential therapeutic regimen for the management of persistent asthma.
Objective To conduct a systematic review and meta-analysis of the effects of SMART in
patients with persistent asthma. Data Sources and Study Selection The databases of
MEDLINE via OVID, EMBASE, the Cochrane Central Register of Controlled Trials, and the …

METHODS. In this meta-analysis and systematic review, the authors searched multiple
databases (Medline via Ovid, Embase, the Cochrane Central Register of Controlled Trials,
and the Cochrane Database of Systemic Reviews) from database inception through
November 2017. Randomized clinical trials or observational studies in which researchers
compare SMART with conventional therapy were reviewed. Outcomes included asthma
exacerbations, mortality, spirometry, asthma control assessed by using the Asthma Control …