… Additionally, small RNA molecules can modulate ATM … ATM mutations. Furthermore, the
design and interpretation of clinical studies assessing TOP1 inhibitors, PARPi (Poly-ADP ribose …

… For instance, poly ADP-ribose polymerase (PARP) predominantly … In response to
increased ROS, ATM further modulates the … of a novel and specific inhibitor of the ataxiatelangiectasia …

… The role of ATM signaling in the DDR has been widely … of its cousins, poly-ADP–ribose
polymerase (PARP) and ataxia … meant to identify novel compounds with radiosensitizing …

… poly (ADP-ribose) polymerase (PARP), ataxia telangiectasia, … critical role in chromatin structure
modulation. Furthermore, it … in ATM signaling pathways to control ATM's activity. Although …

… -resistance, and modulate the immune microenvironment in … exist between the ATM and ATR
signaling pathways, these … evaluated AZD6738 with the poly-ADP ribose polymerase (PARP…

… The recent success of Poly (ADP-ribose) polymerase (PARP) … The in-depth roles of ATM
and ATR signalling pathways in … Conversely, another potential approach to modulate ATM …

… the regulatory role of ATM in modulating macropinocytosis, a … a repair complex and transfers
ADP-ribose to target proteins to … transmitting them to downstream signaling pathways (71). …

… pathways and includes ataxia telangiectasia mutated (ATM) … activates down-stream regulator
ATM. BRCA1 and its binding … of DNA repair and transcriptional modulation.28, 29 PARPi …

… Notably, it was suggested that ATM also phosphorylates and modulates the activity of key …
wide epigenetic changes in AT have provided novel advances in our understanding of how AT …

… coordination of all pathways involved. Some of the most important direct ATM targets are
CHK2 and p53, two downstream effectors that modulate pivotal DDR pathways like cell cycle …