Cellular and synaptic dysfunctions in Parkinson's disease: stepping out of the striatum
N Mallet, L Delgado, M Chazalon, C Miguelez… - Cells, 2019 - mdpi.com
… are autonomous pacemakers, their spiking activity is instead independent of excitatory inputs
[… Together with the EPN, the SNr is one of the output nuclei in the basal ganglia. Like other …
[… Together with the EPN, the SNr is one of the output nuclei in the basal ganglia. Like other …
Generation of human A9 dopaminergic pacemakers from induced pluripotent stem cells
… of synaptic inputs [8]; these autonomous pacemaking action … [53], as increased demand
for Ca 2+ handling exacerbates … the frequency of autonomous pacemaking action potentials …
for Ca 2+ handling exacerbates … the frequency of autonomous pacemaking action potentials …
Mechanism of pacemaker activity in zebrafish DC2/4 dopaminergic neurons
VA Ilin, Q Bai, AM Watson, M Volgushev… - Journal of …, 2021 - Soc Neuroscience
… resistance, and continual, cell-autonomous pacemaker activity, that strengthen the basis for
… currents, suggesting that synaptic inputs to these cells in the intact CNS can modulate their …
… currents, suggesting that synaptic inputs to these cells in the intact CNS can modulate their …
Modeling the pathophysiology of Parkinson's disease in patient-specific neurons
J Feng - Experimental Biology and Medicine, 2021 - journals.sagepub.com
… and relaxation of skeletal muscles needed for the intended … in the basal ganglia are
autonomous pacemakers. Principal … bursts of spontaneous excitatory post-synaptic currents …
autonomous pacemakers. Principal … bursts of spontaneous excitatory post-synaptic currents …
A Network-Level Stochastic Model for Pacemaker GABAergic Neurons in Substantia Nigra Pars Reticulata
K Guimarães, A Duarte - Mathematics, 2023 - mdpi.com
… of output from the sensorimotor basal ganglia. Experimental data … of synaptic input are
referred to as autonomous spiking … neuron (Neuron 1) which spikes regardless of any excitatory …
referred to as autonomous spiking … neuron (Neuron 1) which spikes regardless of any excitatory …
Symmetric and Asymmetric Synapses Driving Neurodegenerative Disorders
D Romaus-Sanjurjo, A Custodia, M Aramburu-Núñez… - Symmetry, 2021 - mdpi.com
… In excitatory synapses, LTP is induced only when both pre- … amount of DA to the basal
ganglia (BG) and forebrain [21]. … , STN neurons lose their autonomous pacemaking due to both …
ganglia (BG) and forebrain [21]. … , STN neurons lose their autonomous pacemaking due to both …
An Agent-Based Model to Reproduce the Boolean Logic Behaviour of Neuronal Self-Organised Communities through Pulse Delay Modulation and Generation of …
L Irastorza-Valera, JM Benítez, FJ Montáns… - Biomimetics, 2024 - mdpi.com
… for patients with implants or pacemakers, limiting its applications… , neurons behave in an
autonomous, unsupervised and … [32], but they are out of phase anyway, and so they have to be …
autonomous, unsupervised and … [32], but they are out of phase anyway, and so they have to be …
[HTML][HTML] Connectivity and functionality of the globus pallidus externa under normal conditions and Parkinson's disease
… of complex connections with the other basal ganglia nuclei and brain regions. Recently, …
in an autonomous manner, which makes their spiking activity independent of excitatory inputs (…
in an autonomous manner, which makes their spiking activity independent of excitatory inputs (…
The globus pallidus orchestrates abnormal network dynamics in a model of Parkinsonism
… -excitation and opto-inhibition) to dissect the specific functional contribution of key cortico-basal
ganglia (… First, STN neurons have autonomous pacemaker firing properties 44 , and there …
ganglia (… First, STN neurons have autonomous pacemaker firing properties 44 , and there …