The multifaceted role of flavonoids in cancer therapy: leveraging autophagy with a double-edged sword

Z Zhang, J Shi, EC Nice, C Huang, Z Shi - Antioxidants, 2021 - mdpi.com
autophagy, suggesting that combining autophagy inhibitors … therapy and the related
mechanisms involved in autophagy … an understanding of the modulation of autophagy (Figure 2). …

Autophagy is a doubleedged sword in the therapy of colorectal cancer

B Zhang, L Liu - Oncology Letters, 2021 - spandidos-publications.com
Autophagy can either stimulate tumor survival or induce … This ‘double-edged sword’ role of
autophagy in colorectal cancer is … In conclusion, autophagy is considered a novel therapeutic

Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect

SM Lim, EA Mohamad Hanif, SF Chin - Cell & Bioscience, 2021 - Springer
… , disease stage and external stimuli. Recently, the emerging role of autophagy as a double-edged
sword in … The therapeutic potential of autophagy modulation has been contentious and …

Chaperone-Mediated Autophagy in Brain Injury: A Double-Edged Sword with Therapeutic Potentials

H Zhang, Y Tian, S Ma, Y Ji, Z Wang, P Xiao… - Molecular …, 2024 - Springer
… We also discuss the potential of CMA as a therapeutic target to treat brain injury and provide
… We also discuss the potential of developing CMA-targeted therapeutic strategies for treating …

Autophagy, a double-edged sword in anti-angiogenesis therapy

J Liu, L Fan, H Wang, G Sun - Medical oncology, 2016 - Springer
… cells, but the function of autophagy induced by anti-… therapy-induced hypoxia and autophagy,
and pay special attention on the exact role of anti-angiogenesis agents induced autophagy

Targeting autophagy in lymphomas: A double-edged sword?

H Zhang - International Journal of Hematology, 2018 - Springer
autophagy and lymphoma are frequently reported. We herein mainly focus on … double-edged
sword of autophagy functions in lymphomas, especially the correlation of autophagy

Autophagy as a double-edged sword in pulmonary epithelial injury: a review and perspective

ZY Li, YF Wu, XC Xu, JS Zhou… - … of Physiology-Lung …, 2017 - journals.physiology.org
autophagy is decreased from its basal level, autophagy is protective; 2) when autophagy is
… be associated with the deleterious function of autophagy in airway epithelial injury, although …

Hydrogen sulfide and autophagy: a double edged sword

D Wu, H Wang, T Teng, S Duan, A Ji, Y Li - Pharmacological research, 2018 - Elsevier
… in order to increase the therapeutic effects by mediating autophagy in human diseases. In
this … and the effects of signaling pathways in H 2 S-mediated autophagy are further discussed. …

Therapeutic potential of autophagy-enhancing agents in Parkinson's disease

TE Moors, JJM Hoozemans, A Ingrassia… - Molecular …, 2017 - Springer
… enhancement of autophagy may be an attractive strategy to combat α-syn aggregation in
PD. Here, we review the potential of autophagy enhancement as disease-modifying therapy in …

[HTML][HTML] Autophagy-driven NETosis is a double-edged sword–review

X Liang, L Liu, Y Wang, H Guo, H Fan, C Zhang… - Biomedicine & …, 2020 - Elsevier
… , and reviews the role of autophagy-driven NETosis in various diseases, in the hope that this
autophagy and NETs and discuss the role of autophagy-driven NETosis in related diseases. …