… protein (WASP) selectively in B lymphocytes (B/WcKO), we and others have revealed a
nonredundant B-cell-intrinsic role of WASP in … of both WASP and N-WASP causes a defect in the …

… Moreover, in mouse models in which only B cells lacked WASp, the contribution of
intrinsic B cell defects in the pathogenesis of autoimmunity has been demonstrated (18, 19). …

… show that WASp-deficient platelets present intrinsic defects that become more severe in …
mice, 20 we hypothesized that WASp-deficient B cells can react against platelets by producing …

… -pair model of human T and B lymphocytes, we show that WASp deficiency differentially …
a cell-autonomous defect contributing to B cell oncogenesis in WAS (cell-intrinsic model). In …

… On the other hand, intrinsic defects of B lymphocyte … new emigrant B cells, which indicates
that the defects of B cell … mosaicism and presence of WASp-expressing cells in their circulation …

… helper cells in both WAS patients and WASP-deficient mice are impaired. This study
demonstrates a B cell-intrinsic role of WASP in generating antigen-specific memory B cells and …

… a deficiency in humoral immune memory. However, the mechanism by which Wiskott-Aldrich
syndrome protein (WASP) … leads to the cell intrinsic autoimmunity. Both mouse and human …

… in WASP-deficient cells, we crossed NPM-ALK/Wasp − /− … be to study WASP and WIP
expression in B cell lymphoma or … the cellular levels of WASP and WIP intrinsically contribute to …

… A main feature of Wiskott-Aldrich syndrome (WAS) is increased susceptibility to autoimmunity.
A key contribution of B cells to … B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome …

… -intrinsic loss of tolerance by positive selection of self-reactive B cells Citation23 and the
production of a broad spectrum of autoantibodies. Citation24 WASP-deficient neutrophils and …