Immune-inflammatory responses in atherosclerosis: role of an adaptive immunity mainly driven by T and B cells

DA Chistiakov, AN Orekhov, YV Bobryshev - Immunobiology, 2016 - Elsevier
Humoral immunity is mediated by B cells that release antigen-specific … of T and B lymphocytes
in atherosclerosis on the basis of studies in humans and animal models of atherosclerosis. …

Immunity in atherosclerosis: focusing on T and B cells

AV Poznyak, EE Bezsonov, TV Popkova… - International Journal of …, 2021 - mdpi.com
… secrete poorly specific natural IgM antibodies, creating a rapid and T-cell-independent
humoral response. Secreted B1 antibodies are polyreactive and are the main defense against …

The role of B cells in atherosclerosis

AP Sage, D Tsiantoulas, CJ Binder… - Nature Reviews Cardiology, 2019 - nature.com
… , IgG, and IgE as well as regulation of T cell responses affecting the progression of this disease,
… the spectrum of B cell involvement in dyslipidaemia and atherosclerosis. B cell receptors: …

Functional role of B cells in atherosclerosis

SD Ma, M Mussbacher, EV Galkina - Cells, 2021 - mdpi.com
atherosclerosis-prone conditions. By summarizing current knowledge of B cells in and beyond
atherosclerosis… While OSE-derived antigens induce humoral response in atherosclerosis, …

Adaptive response of T and B cells in atherosclerosis

DFJ Ketelhuth, GK Hansson - Circulation research, 2016 - Am Heart Assoc
… Particularly, humoral immunity to oxLDL has been proposed to play an important role in
CVD in several studies. It has been shown that plaque size correlates negatively with levels of …

Antibodies in action: the role of humoral immunity in the fight against atherosclerosis

JA Taylor, MA Hutchinson, PJ Gearhart, RW Maul - Immunity & Ageing, 2022 - Springer
… and further stimulate B cell antibody production. B cells in atherosclerosis meanwhile have
a mixed … The current model is that B-1 cells produce protective IgM antibodies in response to …

B cells in atherosclerosis: mechanisms and potential clinical applications

T Pattarabanjird, C Li, C McNamara - Basic to Translational Science, 2021 - jacc.org
B cell–derived Igs modulate atherosclerosis, with a focus on the implications for potential
B-cell–targeted therapies for atherosclerotic … to induce a humoral response to limit the impact of …

Beyond macrophages and T cells: B cells and immunoglobulins determine the fate of the atherosclerotic plaque

H Mangge, F Prüller, W Schnedl, W Renner… - International Journal of …, 2020 - mdpi.com
… fight against atherosclerotic endpoints. This review will reflect the putative role of B cells in
… We will also discuss the clinical therapeutic potency of B cell modulations on the process of …

Follicular B cells promote atherosclerosis via T cell–mediated differentiation into plasma cells and secreting pathogenic immunoglobulin G

C Tay, YH Liu, P Kanellakis, A Kallies, Y Li… - Arteriosclerosis …, 2018 - Am Heart Assoc
… evidence that FO B cells promote development of atherosclerosis via … Mixed chimeric Ldlr
−/− mice whose B cells were deficient in … humoral immunity independently of naïve CD4 + T cell

Gut microbiota and atherosclerosis: role of B cell for atherosclerosis focusing on the gut-immune-B2 cell axis

L Chen, T Ishigami, H Doi, K Arakawa… - Journal of Molecular …, 2020 - Springer
… Furthermore, a potential translational extension of the current research would be to better
characterize the specific humoral immunity in individuals with atherosclerosis. We sought to …