… /Y526) and BLNK (Y96) which are necessary regulators of BTK activation. Further upstream,
… (Y397) whose activation is required for phosphorylation of SYK and BLNK. These results …

… following siRNA-mediated knockdown of SYK or BTK in DHL6 cells… that BTK is activated in
parallel to AKT and that BTK … levels of phosphorylated SYK and BLNK, further suggesting that …

… To this end, we demonstrated that BTK is phosphorylated by AKT on serine/threonine …
Previously, BLNK has been shown to mediate SYK-dependent downstream activation following …

… Inducible activation of Zap70 during B cell development compromised negative selection of
autoreactive B cells, resulting in pervasive autoantibody production. Strict segregation of the …

… To study the interaction of BLNK and BLNK-related molecules (LYN, SYK, BTK) in B cell …
Upon BCR activation, LYN mediated the initial ITAM phosphorylation that could have an …

… of SYK-mediated activation of the BLNK-Ca 2… SYK-dependent activation of the BLNK-BTK-Ca
2+ -NFAT axis, leading to a sustained increase in Ca 2+ concentration and NFAT activation…

… ) where BTK activation is initiated by SYK-dependent phosphorylation … SYK-dependent
phosphorylation of BTK (on Y 551 ) or BLNK… distinct roles for BTK in mediating calcium responses …

… that mediates SYK-dependent BTK activation in CLL cells. Accordingly, the BTK inhibitor
ibrutinib had minimal effect on BCR-mediated … Our finding, that BLNK knockdown resulted in a …

… be a potent inhibitor of Btk activation in B cells that overexpressed … Moreover, our data show
these Myc-mediated increases in … SYK-dependent tonic B-cell receptor signaling is a rational …

… on the receptor-mediated activation of NFAT but no significant effect on the … SYK-dependent
phosphorylation of BLNK promotes the assembly of signalosome complexes containing BTK …