Molecular Pathology of Non-familial Follicular Epithelial–Derived Thyroid Cancer in Adults: From RAS/BRAF-like Tumor Designations to Molecular Risk Stratification

P Soares, AA Povoa, M Melo, J Vinagre, V Maximo… - Endocrine …, 2021 - Springer
… clarified the pathogenesis, at the molecular level, of thyroid carcinomas and … BRAF
V600E-mutated PTC [26] (Table 1). The association of BRAF mutation and PTC at advanced clinical

Molecular evaluation of BRAF gene mutation in thyroid tumors: Significant association with papillary tumors and extra thyroidal extension indicating its role as a …

F Ahmad, R Nathani, J Venkat, A Bharda… - … and molecular …, 2018 - Elsevier
… about the molecular pathogenesis of thyroid cancer, efforts … More than 98% of all BRAF
mutation found in thyroid tumor … outcome along with its clinic pathological correlation was not …

BRaf mutation and papillary thyroid carcinoma patients

L Jiang, H Chu, H Zheng - Oncology letters, 2016 - spandidos-publications.com
pathogenesis and poorer clinicopathological outcomes in patients with PTC (20). In thyroid
cancer, the B-RafV600E mutation … , the association between B-Raf mutations and PTC clinical

BRAF V600E mutation in papillary thyroid cancer is correlated with adverse clinicopathological features but not with iodine exposure

S Özçelik, R Bircan, Ş Sarıkaya, AE Gül… - Endokrynologia …, 2019 - journals.viamedica.pl
… abnormality in the pathogenesis of papillary thyroid carcinoma. We aimed to … Clinical and
histopathological profile of BRAF V600E mutation in conventional papillary thyroid carcinoma

Role and relevance of BRAF mutations in risk stratifying patients of papillary thyroid cancers along with a review of literature

A Krishnamurthy, V Ramshankar… - … Journal of Cancer, 2017 - journals.lww.com
clinical studies have demonstrated an association of BRAF … significance of BRAF V600E
mutation in the pathogenesis of … a high prevalence of BRAF V600E mutation in thyroid cancer. …

[HTML][HTML] Molecular features of aggressive thyroid cancer

G Elia, A Patrizio, F Ragusa, SR Paparo… - Frontiers in …, 2022 - frontiersin.org
Mutated BRAF PTC has been related to different clinical-… pathways implicated in the
pathogenetic process of aggressive TC. … BRAF mutation in papillary thyroid carcinoma: predictive …

Molecular profile and clinicopathologic features of follicular variant papillary thyroid carcinoma

SY Sohn, JJ Lee, JH Lee - Pathology & Oncology Research, 2020 - Springer
… of papillary thyroid carcinoma (FVPTC) has an indolent clinical … by the absence of the BRAF
V600E mutation [17], whereas ~30… Pathogenic variants were defined as known pathogenic

BRAF inhibitors in thyroid cancer: clinical impact, mechanisms of resistance and future perspectives

F Crispo, T Notarangelo, M Pietrafesa, G Lettini… - Cancers, 2019 - mdpi.com
… in the pathogenesis of thyroid cancer. As a multi-kinase inhibitor, sorafenib potentially inhibits
Clinically, BRAF V600E -mutated thyroid cancer cells exhibit primary resistance or poor …

Oncogenic Mutations in PI3K/AKT/mTOR Pathway Effectors Associate with Worse Prognosis in BRAFV600E-Driven Papillary Thyroid Cancer Patients

T Pappa, S Ahmadi, E Marqusee, HL Johnson… - Clinical Cancer …, 2021 - AACR
… The extent to which routine genomic sequencing can identify relevant secondary genomic
alterations among BRAF V600E -mutant papillary thyroid carcinoma (PTC) is unknown. Such …

Incidence of BRAF V600E mutation in patients with papillary thyroid carcinoma: a single-institution experience

S Kure, K Ishino, M Kudo, R Wada… - … Medical Research, 2019 - journals.sagepub.com
BRAF is a potential molecular target in PTC, it is important to clarify the frequency and
clinical significance of BRAF mutationClinically, our institution prefers to carry out active …