… oncogenic Braf signaling in serrated polyps; this finding has implications both for
chemoprevention and for understanding the origin of DNA hypermethylation in cancer generally. …

… genome-wide DNA methylation profiling on fifteen available colon biopsies from eleven …
two distinct colon cancer-related mutations on the DNA methylation pattern, in a single polyp that …

… early colorectal lesions and reported that serrated adenoma … proximal colon and, to exhibit
a high frequency of BRAF mutation … Whereas DNA methylation accumulation in the serrated …

… alternative, serrated pathway of colorectal cancer, abundant … BRAF mutation and synchronous
MLH1 hypermethylation and … examined for DNA hypermethylation in serrated polyps [12–…

… precursor serrated polyps that are localized in the proximal colon. Notably, serrated polyps
… the presence of mutation in BRAF and genome-wide DNA hypermethylation at or around …

… DNA methylation status and clinicopathological features, including tumor locations in early
colorectal lesions with BRAF … mucosa from other types of serrated polyps, but we found no …

… TSA lesions are the rarest form of colorectal serrated polyps (1… to better characterize the DNA
methylation subtypes in CRC. … , and proximal colon location for BRAF mutated tumors, CIMP…

… BRAF mutation and DNA hypermethylation have linked sessile serrated adenomas/polyps
(SSA/Ps) to serrated colorectal … BRAF mutation and CIMP status of serrated polyps were not …

… of colorectal cancers have significantly changed our understanding of these neoplasms.
Serrated polyps… BRAF mutations are more common than KRAS mutations in MVHP and SSA. On …

… of tumors of the digestive system, serrated colorectal lesions … are BRAF V600E mutation
and CpG island hypermethylation, … In this study, DNA methylation status of non-dysplastic SSA/…