HIF-1α and HIF-2α differently regulate the radiation sensitivity of NSCLC cells

E Moreno Roig, AJ Groot, A Yaromina, TC Hendrickx… - Cells, 2019 - mdpi.com
Basal ECAR was measured under control conditions and in … the role of HIF-1/2α on radiation
sensitivity of NSCLC cell line … a prognostic parameter for predicting recurrence and overall …

… HIF1α and lactate dehydrogenase LDH5, key markers of anaerobic metabolism, relate with stem cell markers and poor post-radiotherapy outcome in bladder cancer

MI Koukourakis, C Kakouratos, D Kalamida… - … journal of radiation …, 2016 - Taylor & Francis
… , as predictive markers of radiotherapy outcome for bladder … no data, so far, related to
LDHA expression in bladder cancer… Silencing of HIF1α did not enhance radiosensitivity, …

[PDF][PDF] Determination of Endogenous Radioresistance Biomarkers on HeLa Cells

M Soumboundou, MT Aloy, M Gadji… - European Journal of …, 2020 - academia.edu
HIF-1 had a maximum expression level compared to CAIX … treatment received and predictive
biomarkers determine which … does not affect the radiation sensitivity of multicellular tumor

Constitutive or induced HIF-2 addiction is involved in resistance to anti-EGFR treatment and radiation therapy in HNSCC

P Coliat, L Ramolu, J Jégu, C Gaiddon, AC Jung… - Cancers, 2019 - mdpi.com
… Methods: We treated the radiosensitive Cal27 used as control, … /mTOR/HIF-1 axis to
radiosensitize head and neck cancer cells … low basal HIF-2α expression levels, and no significant …

Hypoxia in solid tumors: how low oxygenation impacts the “Six Rs” of radiotherapy

A Rakotomalala, A Escande, A Furlan… - Frontiers in …, 2021 - frontiersin.org
… “Radiosensitivity” defines the intrinsic sensitivity of tumor … diminishes the tumor lactate level,
increases basal and maximal … HIF factors, and HIF-1 protects tumor endothelial cells from cell …

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

F Cimmino, M Avitabile, VA Lasorsa, A Montella… - BMC medical …, 2019 - Springer
levels (Δβ Hypoxia; Hypoxia probes) but not by HIF1A … enhance radio sensitivity in
nasopharyngeal carcinoma cells [39]. … could further improve in vitro cell line models predictive

HPV, hypoxia and radiation response in head and neck cancer

EL Göttgens, C Ostheimer, PN Span… - The British journal of …, 2018 - academic.oup.com
… could indicate that the increased basal radiosensitivity in HPV-… in many types of human
cancers including HNSCC. Moreover, … POR as a potential predictive biomarker of HAP sensitivity …

HIF1α-dependent and independent pathways regulate the expression of PD-L1 in prostate cancer

ET Xanthopoulou, C Kakouratos, C Nanos… - Medical Oncology, 2023 - Springer
… a major pathway exploited by human cancer types, which is … 20 Gy had no apparent effect
on PD-L1 expression. Culturing … : F western blot images showing the basal expression levels

[HTML][HTML] Radiation resistance: a matter of transcription factors

C Galeaz, C Totis, A Bisio - Frontiers in oncology, 2021 - frontiersin.org
… oxygen levels, therefore determining the activation of the HIF-1 … between Survivin expression
and radiosensitivity suggested … suggests that the expression of BCL-2 is predictive for the …

[PDF][PDF] HIF-1α and HIF-2α differently regulate the radiation sensitivity of NSCLC cells, partly by impairing their metabolic profile

EM Roig, AJ Groot, A Yaromina… - … to cancer therapy, 2018 - cris.maastrichtuniversity.nl
… when assessing basal oxygen consumption rate (OCR) levels (… are a prognostic parameter
for predicting recurrence and overall … Here, we also show that combined HIF1/2α deficiency …