… model of Mtb infection. In this context, we successfully implemented a novel, empirical modeling
framework that supported PAE as part … Additionally, we also used a PK/PD index-based …

… Throughout, we used the fitted models (estimated model parameters) from section 2.2 and
only varied the chemotherapy dosage. The simulated ANC values were obtained from the …

… were defrayed in part by the payment of page charges. This article must therefore be hereby
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… development field is in large part due to the efforts of Peck and Ludden while both were at
… the position of population PK within drug development, and currently, almost all new drug or …

… of LLM-based agents, we now shift our focus to the concept of the “… This section begins with
an investigation into whether these … The core idea of an agent has a historical background in …

… introduce the fundamental concepts of physiologically based … In this section, general
recommendations for PBPK model … , PBPK models can be a valuable support in drug …

… While a potential food effect could not be examined as part of this fasting single-dose phase
I study, it is … For future drug development, these factors require careful consideration and add …

… To fix ideas, let us consider a basic problem of modeling the drug pharmacokinetic-pharmacodynamic
(PK/PD) relationship. For the PK part, we consider a one-compartment model with …

… Realizing the benefits of AI in drug development and … AI/ML In this section, we provide the
basic knowledge that clinical phar… review paper, we covered fundamental concepts of building, …

… drug development studies, since various scenarios, eg, investigating different dosing regimens,
can be simulated (a … Parts of this study were presented at the 29th European Congress of …