… The expression of BCR-ABL gene and multidrug resistance … The next step was to evaluate
the gene expression levels of … of cancer cells to chemotherapy, which can be a determining …

… a patient will develop resistance to imatinib mesylate. This … remain BCR-ABL-positive at
the molecular level, indicating … of BCR-ABL ratio with miRNA-150 was done to determine the …

… have no response to imatinib therapy this rate is rising 15.6%. … aim was to determine the
mutations of the BCR/ABL and to … that increased BCR/ABL mRNA levels detected by RT-qPCR (…

… expectations for imatinib, it has recently been determined that … BCR-ABL mutations can
confer high-level resistance to … altered BCR-ABL protein sequences, which prevent BCR-ABL …

… detect potential markers to predict genetic evolution and development of therapy resistance,
… with second generation BCR–ABL kinase inhibitors would affect the expression level of both …

… , PRC2 expression levels … imatinib mesylate sensitivity, Bewry et al. used an in vitro bone
marrow stroma model in order to establish the role of soluble factors in contributing to imatinib …

… resistance or intolerance were not included in this study); and (6) at least 2 BCR-ABL transcript
level … methods were used to determined BCR-ABL transcript levels. The results of patients…

… to determine the incidence of CML relapse, to identify possible factors relapse rates and to
evaluate the long-term … of TKIs' resistance, as hypothesised by the mechanistic model of CML …

… This study highlights the need for BCR-ABL gene sequence analysis to detect the mutations
… BCR-ABL transcript levels in peripheral blood were assessed using qRT-PCR. Patients with …

… We next determined the long-term efficacy of OGP46 on the … of action of OGP46 on mRNA
expression by mRNA sequencing (… Similarly, the expression levels of 551 and 109 genes were …