Recent findings unveil the pharmacological modulation of imidazoline I 2 receptors (I 2-IR)
as a novel strategy to face unmet medical neurodegenerative diseases. In this work, we
report the chemical characterization, three-dimensional quantitative structure-activity
relationship (3D-QSAR) and ADMET in silico of a family of benzofuranyl-2-imidazoles that
exhibit affinity against human brain I 2-IR and most of them have been predicted to be brain
permeable. Acute treatment in mice with 2-(2-benzofuranyl)-2-imidazole, known as …