Protein-Anchoring Therapy of Biglycan for Mdx Mouse Model of Duchenne Muscular Dystrophy
… of mdx mice upregulates expression of utrophin and other DAPC component proteins on the
sarcolemma, and ameliorates muscle pathology … a counter-equipped running wheel every 2 …
sarcolemma, and ameliorates muscle pathology … a counter-equipped running wheel every 2 …
Non-glycanated biglycan and LTBP4: leveraging the extracellular matrix for Duchenne muscular dystrophy therapeutics
JR Fallon, EM McNally - Matrix Biology, 2018 - Elsevier
… Only NG-biglycan counters dystrophic pathology and … NG biglycan upregulated utrophin at
the sarcolemma motivated … of this protein to ameliorate dystrophic pathology in mdx mice. Two …
the sarcolemma motivated … of this protein to ameliorate dystrophic pathology in mdx mice. Two …
Sarcolemmal targeting of nNOSμ improves contractile function of mdx muscle
DL Rebolledo, MJ Kim, NP Whitehead… - Human molecular …, 2016 - academic.oup.com
… sarcolemmal expression of utrophin and other members of the … for mdx-NOS-M muscle than
the other two groups of mdx mice, … of utrophin improves the dystrophic pathology in the mdx …
the other two groups of mdx mice, … of utrophin improves the dystrophic pathology in the mdx …
Role of proteoglycans and glycosaminoglycans in Duchenne muscular dystrophy
L Carmen, V Maria, JC Morales-Medina… - …, 2019 - academic.oup.com
… Adult biglycan-null mice are mildly dystrophic displaying increased muscle fiber … rhBGN
upregulated utrophin at the sarcolemma and reduced muscle pathology in the mdx mouse model…
upregulated utrophin at the sarcolemma and reduced muscle pathology in the mdx mouse model…
Celecoxib treatment improves muscle function in mdx mice and increases utrophin A expression
C Péladeau, NJ Adam, BJ Jasmin - The FASEB Journal, 2018 - Wiley Online Library
… utrophin A expression in dystrophic muscles. Such methods include increasing the recruitment
of utrophin to the sarcolemma with biglycan … to their fast, glycolytic counterparts (66). Over …
of utrophin to the sarcolemma with biglycan … to their fast, glycolytic counterparts (66). Over …
[图书][B] Proteomic Characterisation of the mdx-4cv mouse model of Duchenne Muscular Dystrophy
S Murphy - 2018 - search.proquest.com
… and increases in the extracellular matrix stabilizers biglycan … samples from the dystrophic
mdx mouse and from biopsy … the sarcolemma through interactions with dystrophin-utrophin and …
mdx mouse and from biopsy … the sarcolemma through interactions with dystrophin-utrophin and …
Duchenne muscular dystrophy: pathogenesis and promising therapies
M Chang, Y Cai, Z Gao, X Chen, B Liu, C Zhang… - Journal of …, 2023 - Springer
… Dystrophin connects the sarcolemma to the cytoskeleton of actin via the DAPC … utrophin
and DAPC-related component β-dystroglycan, and improves NMJ morphology in an mdx mouse […
and DAPC-related component β-dystroglycan, and improves NMJ morphology in an mdx mouse […
Proteomic profiling of the dystrophin complex and membrane fraction from dystrophic mdx muscle reveals decreases in the cytolinker desmoglein and increases in …
S Murphy, H Brinkmeier, M Krautwald, M Henry… - Journal of Muscle …, 2017 - Springer
… to the dystrophin complex in the sarcolemma membrane. … -day-old mdx mouse model of
Duchenne muscular dystrophy (… of the inflammatory pathology of dystrophic muscles have …
Duchenne muscular dystrophy (… of the inflammatory pathology of dystrophic muscles have …
[HTML][HTML] Promising therapeutic approaches of utrophin replacing dystrophin in the treatment of Duchenne muscular dystrophy
R Wu, Y Song, S Wu, Y Chen - Fundamental Research, 2022 - Elsevier
… dystrophin recovery effects in the sarcolemma of mdx mouse … -102 is a recombinant biglycan
that can improve muscle health, … utrophin as well as the muscle strength and pathology of …
that can improve muscle health, … utrophin as well as the muscle strength and pathology of …
[HTML][HTML] Current translational research and murine models for Duchenne muscular dystrophy
M Rodrigues, Y Echigoya, S Fukada… - Journal of …, 2016 - content.iospress.com
… Biglycan, is a proteoglycan found endogenously in mice and … membrane by recruiting
utrophin to the sarcolemma [90]. … utrophin and reduces muscular dystrophy in mdx mice [91]. …
utrophin to the sarcolemma [90]. … utrophin and reduces muscular dystrophy in mdx mice [91]. …