The mammalian septin interactome

K Neubauer, B Zieger - Frontiers in cell and developmental biology, 2017 - frontiersin.org
… important mammalian septin interactions with a special focus on the clinically relevant septin
… The composition of the septin complex is cell-type specific and essential for certain functions…

Septin structure and filament assembly

NF Valadares, H d' Muniz Pereira, AP Ulian Araujo… - Biophysical …, 2017 - Springer
… different septin monomers, and in the case of mammalian septins this … septin of the
hetero-complex occupies a specific position. … with a series of biochemical assays in which the …

[HTML][HTML] Structure and function of Septin 9 and its role in human malignant tumors

J Sun, MY Zheng, YW Li, SW Zhang - World Journal of …, 2020 - ncbi.nlm.nih.gov
… SEPT9 occupies the ends of mammalian octameric SEPT complex. The SEPT9 has a stable
multimeric structure, promotes the polymerization of each subunit, and plays a key role in …

Biochemical and morphological characterization of SEPT1 in mouse brain

H Ito, R Morishita, M Noda, I Iwamoto… - Medical Molecular …, 2020 - Springer
… In mammals, nervous tissues abundantly contain septins and … selectively formed the complex
with SEPT5 in DJM-1 cells [14]… , we carried out biochemical and morphological analyses of …

[HTML][HTML] Molecular recognition at septin interfaces: the switches hold the key

HVD Rosa, DA Leonardo, G Brognara… - … of molecular biology, 2020 - Elsevier
… first four crystal structures of heterodimeric septin complexes. We describe in detail …
mammalian heterocomplexes [4,5,19,22]. To contribute to a fuller understanding of both biochemical

Spatial effects− site-specific regulation of actin and microtubule organization by septin GTPases

ET Spiliotis - Journal of cell science, 2018 - journals.biologists.com
… with distinct organization and biochemical makeup. This Review … of septin complexes – ie
the presence of specific septin … that septins are associated with the mammalian cytoskeleton, …

The cytoskeletal protein septin 11 is associated with human obesity and is involved in adipocyte lipid storage and metabolism

N Moreno-Castellanos, A Rodríguez, Y Rabanal-Ruiz… - Diabetologia, 2017 - Springer
… , body composition analysis and comorbidity evaluations … rings are composed of
heteroligomeric septin complexes, we … been provided by our biochemical studies showing that …

Unearthing the role of septins in viral infections

JE Khairat, MNA Hatta, N Abdullah… - Bioscience …, 2024 - portlandpress.com
mammalian septins into four subgroups is essential because individual septins from each
group can form septin complexes … of cell biology, pathophysiology, and biochemistry studies, …

GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis

M Abbey, C Hakim, R Anand, J Lafera, A Schambach… - Scientific reports, 2016 - nature.com
Biochemical purification and structural analysis of a human SEPT2-SEPT6-SEPT7 trimeric
complex … However, studies on the role of GTPase activity of mammalian septins have been …

Septin 9_i2 is downregulated in tumors, impairs cancer cell migration and alters subnuclear actin filaments

P Verdier-Pinard, D Salaun, H Bouguenina… - Scientific reports, 2017 - nature.com
… , but also in the control of mammalian cell migration 2 . These … Sept9 in the next octameric
septin complex via an NC interface to … We implemented a biochemical assay on cell lysates to …