… –receptor interactions; however, the reasons for diversity in … lipid structures affect biological
functions. We focus on … phenotypes of knockout animals, we identify new lipid functions, but …

… HTS methods used today for hit identification, organized in two main flavors: biochemical …
described above, where the alteration of enzyme/receptor function or the inhibition of probe/…

… Knowing the advantages/disadvantages of each technique is … protein receptors signaling by
disrupting lipid rafts, membrane … be identified by MS, allowing the interpretation of biological …

… number of receptor sequences were identified through gene … the biological target. The
GPCRdb allows users to upload a … The GPCRdb pharmacophore method is also new, in that it …

… and to identify drug candidates (6). New multidisciplinary … of membrane-bound receptors,
including GPCRs, receptor … -based methods have been applied to study various biological …

… identify common operational principles that might guide our search for novel … Biological
membranes are functionalized by the incorporation of membrane proteins that serve as receptors…

… For further reading into the specific biological applications of … receptor type 1 (NTSR1), a
G-protein coupled receptor (GPCR… challenges in identifying membrane protein interactions and …

… analysis for biochemical processes and identifying molecular … scientific research involving
ligand-receptor interactions (Fig. 4). … tag labeled techniques aiming to clarify ligand-receptor in…

… technique, the use for quantification or comparing biological … providing indirect evidence
for physical receptor-receptor … of receptor complexes along with methods used to identify …

… Biological methods for identifying GPCR oligomers in cells and tissues or in recombinant
mammalian expression systems presently include energy transfer-based methods […