General considerations of dose-effect and dose-response relationships
DB Moffett, MM Mumtaz, DW Sullivan Jr… - … on the Toxicology of …, 2022 - Elsevier
… as the search for true disease-specific biomarkers continues. … health risk assessment was
conducted by evaluating dose … used to inform target tissue dose extrapolation and estimation of …
conducted by evaluating dose … used to inform target tissue dose extrapolation and estimation of …
[HTML][HTML] Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment
RA Clewell, CM Thompson, HJ Clewell III - Chemico-Biological Interactions, 2019 - Elsevier
… relationship could be described as a linear dose response. … dose-response for mutations
may be useful as a biomarker … data have greatly informed mode of action analysis for Cr(VI). …
may be useful as a biomarker … data have greatly informed mode of action analysis for Cr(VI). …
How do biomarkers dance? Specific moves of defense and damage biomarkers for biological interpretation of dose-response model trends
S Colas, S Le Faucheur - Journal of Hazardous Materials, 2024 - Elsevier
… to build dose-response curves to feed in risk assessments of … biomarker OR defense
biomarker AND ecotoxicology AND … or biphasic trends in relation to the biomarker type -damage …
biomarker AND ecotoxicology AND … or biphasic trends in relation to the biomarker type -damage …
Risk assessment of occupational pesticide exposure: Use of endpoints and surrogates
SC Machado, I Martins - Regulatory Toxicology and Pharmacology, 2018 - Elsevier
… to the pesticides exposure, biomarkers called endpoints are … conclusions of risk assessments
to make informed decisions … of the dose-effect and dose-response relationships, ie, …
to make informed decisions … of the dose-effect and dose-response relationships, ie, …
[HTML][HTML] Opportunities and challenges related to saturation of toxicokinetic processes: implications for risk assessment
YM Tan, HA Barton, A Boobis, R Brunner… - Regulatory Toxicology …, 2021 - Elsevier
… dose response indicative of metabolic induction, saturation, and changes in the external-internal
dose relationship … time points to determine appropriate biomarkers (parent and major …
dose relationship … time points to determine appropriate biomarkers (parent and major …
Transcriptomic biomarkers in safety and risk assessment of chemicals
DT Szabo, AA Devlin - Biomarkers in toxicology, 2019 - Elsevier
… toxicity responses observed from combustible cigarette smoke exposure. These transcriptomic
studies establish a baseline for future analysis that can better inform the FDA of the risks …
studies establish a baseline for future analysis that can better inform the FDA of the risks …
Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans
T Sahota, M Danhof, O Della Pasqua - Mutagenesis, 2016 - academic.oup.com
… and biomarkers or intermediate measures of drug effect in … recognition that non-linear dose
responses are observed for at … of the quantitative analysis of dose–response relationships in …
responses are observed for at … of the quantitative analysis of dose–response relationships in …
[HTML][HTML] Probabilistic risk assessment–the keystone for the future of toxicology
… produced the observed biomarker concentrations measured in … , or, when an exposure-biomarker
relation is linear, a more … plays a critical role in informing us whether a given dose of a …
relation is linear, a more … plays a critical role in informing us whether a given dose of a …
Exposure assessment of process-related contaminants in food by biomarker monitoring
IMCM Rietjens, P Dussort, H Günther, P Hanlon… - … of Toxicology, 2018 - Springer
… of the different biomarkers in relation to exposure scenario’s and risk assessment, and (6) …
exposure to process-related contaminants in food and thus to better inform risk assessment. …
exposure to process-related contaminants in food and thus to better inform risk assessment. …
Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach
JS Tsuji, ET Chang, PR Gentry, HJ Clewell… - … reviews in toxicology, 2019 - Taylor & Francis
… We present here an approach for a cancer risk assessment for … in the concentration-response
relationship between lung and … dose (eg mg or mg/L-years) or arsenic biomarkers. …
relationship between lung and … dose (eg mg or mg/L-years) or arsenic biomarkers. …