… valuable source of biotin is human gut microbiota producing … [1], which also describes the
biotin active transport across the blood–… in biotin-uptake; this mechanism is inhibited by biotin …

… state of knowledge in biotin nutrition in humans and, … The anticonvulsants primidone and
carbamazepine inhibit biotin uptake into brush border membrane vesicles from human intestine…

… -seizure medications target ion channels to inhibit neuronal … The reduced biotin status may
be caused by increased biotin … and is well absorbed in the intestine [48]. In addition to 5-MTHF…

… Anticonvulsant drugs may compete with biotin in the human intestine, and inhibit the
transport of bi‑ otin by influencing the substrate transport system in the enterocyte brush border …

… synthase inhibitor had no effect on the hypotensive action of biotin supplementation [150 mg
biotin/… In isolated pancreatic islets, treated with inhibitors of different signaling pathways, we …

… , is a broad-spectrum antiepileptic drug. Gabapentin exhibits dose-… solute transporter localized
in the upper small intestine. … inhibited uptake of 3 H-biotin into CHO cells overexpressing …

… inhibition of intestinal biotin uptake, accelerated biotin … have been found to inhibit the intestinal
uptake of biotin, 39 likewise … been reported to displace biotin from biotinidase and this is …

… AEDs that are associated with biotin depletion include … Inhibition in the transport of biotin
across intestinal mucosa and … roles in both intestinal absorption and function of biotin, may …

… At least in part this appears to be mediated via inhibition in intestinal (and colonic) biotin …
intestinal biotin uptake process appears to be sensitive to the effect of the anticonvulsant drugs …

… , interventions, leaving unclear its potential to inhibit disease progression in this disorder. …
containing raw eggs rich in avidin that chelates biotin and avoids its intestinal absorption [27]. …