New therapeutic approaches to inherited metabolic pediatric epilepsies

PL Pearl, I Tokatly Latzer, HHC Lee, A Rotenberg - Neurology, 2023 - AAN Enterprises
… , antiseizure medications are indicated based on seizure … and biotin responsive basal
ganglia disease are also biotininhibitors that inhibit phe intestinal absorption and reuptake by …

[HTML][HTML] Revised DA-CH reference values for the intake of biotin

A Jungert, S Ellinger, B Watzl, M Richter… - European Journal of …, 2022 - Springer
… Since anticonvulsants impair intestinal absorption of biotin [… requirement during long-term
antiepileptic therapy can be … inflammatory bowel disease may also cause functional biotin

Opportunities and challenges for inhibitors targeting citrate transport and metabolism in drug discovery

L Zhang, W Hu, Z Qiu, Z Li, J Bian - Journal of Medicinal …, 2023 - ACS Publications
… and intestines and exhibit a greater affinity for succinate as compared to citrate. Inhibiting
experiments demonstrated that the biotinylated radicicol bound to human ACLY. (128) At …

Pharmacological Therapy in Inborn Errors of Metabolism

AM Das, S Illsinger - Drug Discovery and Evaluation: Methods in Clinical …, 2020 - Springer
Inhibition of human HPPD was demonstrated in the human liver by … Based on the high rate
of gastrointestinal side effects of … of biotin from dietary sources and in biotin recycling. Free …

[HTML][HTML] 2018.3-25. hair loss

SA Ruiz-Tagle, MM Figueira, V Vial… - CME, 2023 - odermatol.com
… Phytates present in cereals and legumes inhibit the zinc absorption [30]. … to the biotin
status [66]. To achieve its active form and to be absorbed in the intestine, biotin is subjected to a …

[HTML][HTML] Amino acids in the development of prodrugs

N Vale, A Ferreira, J Matos, P Fresco, MJ Gouveia - Molecules, 2018 - mdpi.com
… to the lack of a transport system on the intestinal tract capable of … that are potent inhibitors
of human cytomegalovirus (HCMV) … uptake of 3 H-biotin into Chinese Hamster Ovary cells …

[图书][B] Effects of clinical ketogenic diet therapy for pediatric epilepsy on the gut microbiota and seizure resistance

GRT Lum - 2023 - search.proquest.com
… reduces seizure symptoms when other anti-epileptic drugs … , polyamine biosynthesis and
biotin biosynthesis in response to … acid through direct AMPA receptor inhibition. Brain, 139(2), …

… -8 and coreceptor LRP6 in Wnt/β-Catenin pathway and in vitro analysis of fucoidan extract from Sargassum echinocarpum as β-catenin inhibitor in breast cancer cell …

RA Laeliocattleya, Y Yunianta, Y Risjani… - Journal of …, 2023 - Taylor & Francis
… and cisplatin biotin as drug control ligands, representing standard commercial anticancer
drugs. … The accurate prediction of human intestinal absorption of drugs is crucial in identifying …

Sesamin, a Naturally Occurring Lignan, Inhibits Ligand‐Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXRα) and Pregnane X Receptor (PXR …

TS Tai, N Tien, HY Shen, FY Chu… - … Alternative Medicine, 2019 - Wiley Online Library
… We used two cell lines (hepatocytes and intestinal epithelia) to … 24 h and incubated with these
biotinylated probes (2 μg each) … Our results so far revealed that SSM did not inhibit hepatic …

Current explorations of nutrition and the gut microbiome: a comprehensive evaluation of the review literature

LA Frame, E Costa, SA Jackson - Nutrition reviews, 2020 - academic.oup.com
… absorption, and reduce intestinal transit time. Contrastingly, … the gut. The microbiota utilize
and produce micronutrients; the bidirectional relationship between micronutrition and the gut