Design, synthesis, and biological evaluation of tetrahydroisoquinoline-based diaryl urea derivatives for suppressing VEGFR-2 signaling
Y Huang, Y Zhang, J Li, X Ma, M Hu, Y Yang… - Anti-Cancer …, 2019 - journals.lww.com
… upon treatment with diphenyl azidophosphate (DPPA). … novel modulators of VEGFR-2
signaling, the pharmacorphore-combination strategy was introduced by incorporating diaryl urea …
signaling, the pharmacorphore-combination strategy was introduced by incorporating diaryl urea …
Design, synthesis and docking study of novel picolinamide derivatives as anticancer agents and VEGFR-2 inhibitors
… urea) derivatives and their inhibitory activity against VEGFR-2 revealed that substituted
phenyl urea derivatives … than the phenyl urea derivative 7a as VEGFR-2 inhibitors. Moreover, …
phenyl urea derivatives … than the phenyl urea derivative 7a as VEGFR-2 inhibitors. Moreover, …
Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies
… urea derivatives at position-4 and vinyl moiety at position-2 to successfully deliver a novel
series of potent antitumor agents as VEGFR-2 … the O linker and the biphenyl urea moieties. The …
series of potent antitumor agents as VEGFR-2 … the O linker and the biphenyl urea moieties. The …
Facile one-pot sequential synthesis of novel diaryl urea derivatives and evaluation of their in vitro cytotoxicity on adenocarcinoma cells
F Azimian, M Hamzeh-Mivehroud… - Medicinal Chemistry …, 2021 - Springer
… Discovery of VEGFR-2 inhibitors capable of intervening with … Structurally diverse VEGFR-2
inhibitors (ATP analogs) with … core, and sorafenib 3 with a urea segment [7] (Fig. 1). …
inhibitors (ATP analogs) with … core, and sorafenib 3 with a urea segment [7] (Fig. 1). …
Anti-angiogenic therapy: Strategies to develop potent VEGFR-2 tyrosine kinase inhibitors and future prospect
L Shi, J Zhou, J Wu, Y Shen, X Li - Current Medicinal Chemistry, 2016 - ingentaconnect.com
… urea derivates 12 were also validated as novel VEGFR-2 … VEGFR-2 inhibition could be
obtained by linking a diphenyl-… two pharmacophoric units are essential for VEGFR-2 inhibition. …
obtained by linking a diphenyl-… two pharmacophoric units are essential for VEGFR-2 inhibition. …
Identification of new pyrrolo [2, 3-d] pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling
… In the current study, a series of novel pyrrolo[2,3-d]pyrimidine … urea tail showed the most
potent nanomolar VEGFR-2 … NH linkers and the biphenyl urea in the designed compounds were …
potent nanomolar VEGFR-2 … NH linkers and the biphenyl urea in the designed compounds were …
Design, synthesis and evaluation of novel thienopyrimidine-based agents bearing diaryl urea functionality as potential inhibitors of angiogenesis
A Faraji, TO Bakhshaiesh, Z Hasanvand… - European Journal of …, 2021 - Elsevier
… -1,3,4-thiadiazole-aryl urea derivatives 11a-m to evaluate their … vessels, and inhibition of
VEGFR-2 phosphorylation were … of novel drugs to treat tumors, particularly prostate cancer. …
VEGFR-2 phosphorylation were … of novel drugs to treat tumors, particularly prostate cancer. …
Design, synthesis, and anti-proliferative evaluation of new quinazolin-4 (3H)-ones as potential VEGFR-2 inhibitors
K El-Adl, AGA El-Helby, RR Ayyad, HA Mahdy… - Bioorganic & Medicinal …, 2021 - Elsevier
… on the development of novel VEGFR-2 inhibitors. Many … a and 34 c ) instead of urea moiety
increased enzymatic activity and … 1 N–H of the urea unit of sorafenib formed a hydrogen bond …
increased enzymatic activity and … 1 N–H of the urea unit of sorafenib formed a hydrogen bond …
Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors
AE Abdallah, RR Mabrouk, MMS Al Ward… - … of Enzyme Inhibition …, 2022 - Taylor & Francis
… of VEGFR-2 inhibitors, 17 novel compounds were designed … and donors in some VEGFR-2
inhibitor drugs as Regorafenib … So that urea and amide moieties were designed in this work …
inhibitor drugs as Regorafenib … So that urea and amide moieties were designed in this work …
Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrazolo [3, 4-d] pyrimidine derivatives as BRAFV600E and VEGFR-2 dual inhibitors
Y Wang, S Wan, Z Li, Y Fu, G Wang, J Zhang… - European Journal of …, 2018 - Elsevier
… for VEGFR-2 inhibition in addition to BRAF V600E inhibition, we docked 1 into the co-crystal
structure of Sorafenib and VEGFR-2 to … The diaryl urea portion extended into the large …
structure of Sorafenib and VEGFR-2 to … The diaryl urea portion extended into the large …