An adverse tendency induced by the environmental estrogens in female reproductive health
is one serious problem worldwide. Diethylstilbestrol (DES), as a synthetic estrogen, is still
used as an animal growth stimulant in terrestrial livestock and aquaculture illegally. It has
been reported to negatively affect ovarian function and oogenesis. Nevertheless, the
mechanism and toxicity of DES on oocyte meiotic maturation are largely unknown. Herein,
we found that DES (40 μM) intervened in mouse oocyte maturation and first polar body …

Bisphenol B (BPB), a substitute of bisphenol A (BPA), is widely used in the polycarbonate
plastic and resins production. However, BPB proved to be not a safe alternative to BPA, and
as an endocrine disruptor, it can harm the health of humans and animals. In the present
study, we explored the effects of BPB on mouse oocyte meiotic maturation in vitro. We found
that 150 μM of BPB significantly compromised the first polar body extrusion (PBE) and
disrupted the cell cycle progression with meiotic arrest. The spindle assembly and …