… have shown that blocking sepsis-induced DC apoptosis or … apoptosis could be a new
therapeutic approach in sepsis. Further, exploring potential therapeutic targets related to apoptosis …

… organs during sepsis, and an inhibition of apoptosis by using … identification of infections,
rational employment of antibiotics, … -1/PD-L1 blockade can be used to treat sepsis. To investigate …

… search on therapeutic strategies aiming at treating sepsis or … Several authors have described
the effect of C5a blockade in … ), anti-C5a treatment lowered thymocyte apoptosis by 80%. …

… to consider that a single therapeutic strategy or medication would provide … , blocking
PD-1/PD-L1 pathway with anti-PD-1 or anti-PD-L1 antibodies in septic patients decreased apoptosis …

… , many therapeutic strategies targeting macrophages may … apoptosis could be a promising
therapy for sepsis caused by … clearing extensive RONS and blocking macrophages pyroptosis. …

… , therapeutic strategies aiming to modulate or block apoptosis may present … apoptosis
blockade in such a short time-frame. Therefore, treating the consequences of lymphocyte apoptosis …

… ER mediated cell apoptosis, was reestablished by melatonin, probably through the MAPK/ERK
pathway (66). Lastly, melatonin protects mitochondria by blocking the overexpression of …

… release of anti-inflammatory cytokines, the apoptosis of T cells, B cells and … rationale for
blocking activation of the innate immune system as a component of the early therapy of sepsis …

… into novel targeted therapeutic strategies. Pivotal for the … ; key findings in sepsis are the
delayed apoptosis of neutrophils … IL-12 and IL-18; blocking or eliminating these cytokines confers …

… in sepsis, reversal of exhausted T-cells by the blocking PD-1/… to mice suffering from sepsis
could reduce the apoptosis of … -L1 antibody could reduce the apoptosis of T lymphocytes in …