Brain targeting with docosahexaenoic acid as a prospective therapy for neurodegenerative diseases and its passage across blood brain barrier

M Hachem, M Belkouch, AL Van, M Picq… - Biochimie, 2020 - Elsevier
… More recently, the same team has shown by an ex vivo MRI study that the … review sums
up the current knowledge of the brain targeting with a neuroprotective omega-3 fatty acids

Efficient docosahexaenoic acid uptake by the brain from a structured phospholipid

M Hachem, A Géloën, AL Van, B Foumaux… - Molecular …, 2016 - Springer
… By combining in vitro and in vivo experiments, our findings report … Our findings identify
AceDoPC as an efficient way to … C]AceDoPC injection using phosphor imaging. a and b Slices at …

[HTML][HTML] Esterification of Docosahexaenoic Acid Enhances Its Transport to the Brain and Its Potential Therapeutic Use in Brain Diseases

A Lo Van, N Bernoud-Hubac, M Lagarde - Nutrients, 2022 - mdpi.com
… This review also introduces some studies focusing on the effects of DHA-containing … This
was observed in an experimental stroke with a more significant lower size of post-stroke lesions …

Incorporation of docosahexaenoic acid (DHA) enhances nanodelivery of antiretroviral across the blood-brain barrier for treatment of HIV reservoir in brain

P Guo, M Si, D Wu, HY Xue, W Hu, HL Wong - Journal of controlled release, 2020 - Elsevier
… , and male only for imaging) were purchased from Charles … Then we evaluated if nanoARV
caused undesirable toxicity … as a more established brain targeting strategy was also shown …

[HTML][HTML] AceDoPC, a structured phospholipid to target the brain with docosahexaenoic acid

M Lagarde, M Hachem, M Picq, M Guichardant… - OCL, 2016 - ocl-journal.org
… The post-stroke brain lesions, assessed by magnetic resonance … the brain in a post-stroke
situation. The mechanism of this is not clear, but recent findings suggest that AceDoPC ® , in …

Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC®

N Bernoud-Hubac, M Hachem, AL Van, M Picq… - 2017 - ocl-journal.org
Findings suggested that DHA is better incorporated into the … of stroke, non-esterified DHA
or AceDoPC ® solubilized in plasma was intravenously injected. Magnetic resonance imaging

[HTML][HTML] Targeting the brain with a neuroprotective omega-3 fatty acid to enhance neurogenesis in hypoxic condition in culture

A Lo Van, N Sakayori, M Hachem, M Belkouch… - Molecular …, 2019 - Springer
evaluated as the ratio of Tuj1 positive cell number over the total cell number (b). Astrogenesis
rates are evaluated … Our motivation for exploring the effects of brain targeting with AceDoPC…

[HTML][HTML] Emerging role of phospholipids and lysophospholipids for improving brain docosahexaenoic acid as potential preventive and therapeutic strategies for …

M Hachem, H Nacir - International Journal of Molecular Sciences, 2022 - mdpi.com
… of brain targeting with DHA for prevention and potential … The authors used multimodal MRI
to evaluate in vivo the … -glycerophosphocholine) in experimental stroke in rats undergoing …

Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases

AL Van, N Sakayori, M Hachem, M Belkouch, M Picq… - Biochimie, 2016 - Elsevier
… This review aims to briefly describe identified mechanisms of DHA transport … brain targeting
of DHA and DHA-derived neuroprotective metabolites might be an alternative to treatments

[HTML][HTML] Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury

Y Li, M Zhang, S Li, L Zhang, J Kim, Q Qiu, W Lu… - Asian Journal of …, 2023 - Elsevier
… In this study, docosahexaenoic acid (DHA) was chosen as it … liposomes to increase its
brain-targeting capability. The liposomes … and placed in an MRI machine with a specific rat holder. …