… The central component of the Sec system is the transmembrane SecYEG channel (also
known as the SecYEG translocon; SEC61 in eukaryotes; Fig. 1c), which translocates …

… addition, the bacterial Sec machinery shares the cytoplasmic membrane with a host of other
… The decision whether to export substrate proteins by the translationally coupled pathway or …

… and through it bacterial effector proteins are transported into a … -strand break (DSB) at the
locus of interest and its repair via either … Another very special export strategy of protein is using …

… Most exported proteins in bacteria are transported across the … Additionally, a helix breaking
residue is often found at the -4 to -6 … can make its way to the other side of the membrane. …

… bacteria of a variety of different export systems, the industrial production of (heterologous)
proteins has relied primarily on the Sec-… Below an overview is given for using these systems in …

… In addition, many proteins exported by the UT mechanism … bacteria, the folding of exported
proteins can also be stabilized by other types of covalent linkages between amino acid side …

… into or across the cytoplasmic membrane. Bacteria use multiple protein transport systems
in parallel, but the majority of proteins engage two distinct targeting systems. One is the co-…

… of proteins that are exported from the site of synthesis of all bacterial proteins, the cytoplasm,
into the … Breaking the contact at the side site on SecB within a wild-type complex results in …

… Sec translocase complex or the TAT system The effectors that require secretion through the
type II and V systems are first exported … translocation across the IM through the Sec system (…

… systems in Gram-negative bacteria was a major breakthrough, the downside has been that
secretion systems … -GC Gram-positive bacteria, they produce a second membrane composed …