… the CD8 + T cell response (for example, through immunization) … T cell receptor diversity
across the broader CD8 + T cell … on rapid expansion and lytic function of CD8 + T cells. However, …

… of anti-viral T cells that show broad cross-reactivity across … /IL2 expansion results in
activation of CD8+ T cells. Washing … -1 vaccine regimens that were designed to elicit HIV-1-specific …

… CD4 + T cell “help” in our in vitro HIV-1-specific cytotoxic T cell … therapeutic vaccine strategy
for inducing robust CD8 + T … Our results with DC-primed CD8 + T cells fit with a broad CTL …

… expanding highly functional virus-specific cytotoxic CD8 + T cells, … of TCR signal alone was
sufficient to drive proliferation of … treatment is that in contrast to broadly antigenic HIV vaccines…

… , a T-cell response that is able to recognize a much broader … through viral replication, clonal
expansion of latently infected … can be used to inform future vaccines or therapy strategies. …

… evidence for antigen-driven clonal expansion in vivo and … T cell responses are broad and
heterogeneous (38, 39), we … To study HIV-1–specific cells, we used overlapping Gag peptides, …

… that the expansion of HIV-specific CD8 + T cells correlates … clones of CD8 + T cells with
different TCR rearrangements … a functional vaccine that induces broad CD8 + T cell responses. …

… status and function of HIV-specific CD8 + T cells after long-term ART … CD8 + T cells with
high expansion (P<0·0008) and cytotoxic capacity (P=0·02) after in vitro recall, albeit at low cell …

… , as activation through TCR stimulation sensitizes T cells to … T cell therapy involving the
expansion of natural virus-specific … With recent advances in cell therapy and vaccine platforms …

… We used a T cell receptor (TCR)-dependent activation… + and CD8+ T cell responses, indicating
a broader relationship than … + and CD8+ T cell responses in a chronic state of expansion, …