Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome

CM Leopold Wager, CR Hole, KL Wozniak… - Frontiers in …, 2016 - frontiersin.org
… of manipulation and evasion strategies used by Cryptococcus… , calcium flux and protease
activity, rendering the phagosome … of Cryptococcus to proliferate inside macrophages and then …

Dragotcytosis: elucidation of the mechanism for Cryptococcus neoformans macrophage-to-macrophage transfer

Q Dragotakes, MS Fu, A Casadevall - The Journal of Immunology, 2019 - journals.aai.org
… of yeast cells in some phagosomes, particularly larger ones … in macrophages where the
fungal cell cannot escape, the … and manipulation of the phagosome by a fungal pathogen. …

Lipids affect the Cryptococcus neoformans-macrophage interaction and promote nonlytic exocytosis

SJ Nolan, MS Fu, I Coppens… - Infection and …, 2017 - Am Soc Microbiol
… during the interaction of Cryptococcus neoformans with macrophages in … As the phagosomes
of macrophages have limited glucose … An initial event in the escape of C. neoformans from …

Formation and maturation of the phagosome: a key mechanism in innate immunity against intracellular bacterial infection

HJ Lee, Y Woo, TW Hahn, YM Jung, YJ Jung - Microorganisms, 2020 - mdpi.com
Phagosomes then interact with lysosomes to form … on phagosome maturation among the
various immune evasion … phagocytes, including macrophages, neutrophils and dendritic cells. …

The outcome of the Cryptococcus neoformans–macrophage interaction depends on phagolysosomal membrane integrity

…, MS Fu, Q Dragotakes, C Coelho… - The Journal of …, 2018 - journals.aai.org
… by macrophages it resides within a mature phagosome, where it … neoformans escape from
macrophages during this time course … Chemical manipulation of PMP affects the outcome of C. …

Real-time visualization of phagosomal pH manipulation by Cryptococcus neoformans in an immune signal-dependent way

EJ Santiago-Burgos, PV Stuckey… - Frontiers in Cellular …, 2022 - frontiersin.org
interactions driving disease establishment is Cryptococcus’s … or Mycobacteria, escape from
the phagosome before it acidifies; … albicans’s phagosomes acidify faster in M1 macrophages

Dangerous Liaisons: Interactions of Cryptococcus neoformans with Host Phagocytes

EA Gaylord, HL Choy, TL Doering - Pathogens, 2020 - mdpi.com
… neoformans may manipulate phagosome maturation to enhance its own … by macrophages
are degraded in the phagosome, C. neoformans uses at least three mechanisms to escape

Cholesterol and sphingomyelin are critical for Fcγ receptor–mediated phagocytosis of Cryptococcus neoformans by macrophages

AM Bryan, JK You, G Li, JH Kim, A Singh… - Journal of Biological …, 2021 - ASBMB
macrophages play a key role in the outcome of a cryptococcal infection, it is crucial to understand
factors that mediate phagocytosis of C… govern macrophages' ability to phagocytose C. …

Control of phagocytosis by microbial pathogens

E Uribe-Querol, C Rosales - Frontiers in immunology, 2017 - frontiersin.org
… , and even physical escape from the phagosome. Our … This last step is enhanced through
interactions with GTPase-… by macrophages by preventing fusion between phagosomes and …

[HTML][HTML] Characterizing the mechanisms of nonopsonic uptake of cryptococci by macrophages

J Lim, CJ Coates, PI Seoane, M Garelnabi… - The Journal of …, 2018 - journals.aai.org
evade clearance by the host immune system by hiding and persisting within macrophages
(2… this interaction for Cryptococci remains unknown. In this article, we show that nonopsonized …