[HTML][HTML] Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities

S Li, C Sampson, C Liu, H Piao, HX Liu - Cell Communication and …, 2023 - Springer
… α6 does not have an impact on stemness and self-renewal. … with Rac1 during peripheral
regeneration to regulate fibroblast-… botulinum C3 exoenzyme, an inhibitor of Rho GTPase. This …

[图书][B] Self-tracing Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells to Map Transplant Integration

P Chan - 2019 - search.proquest.com
… Preliminary in vivo data suggest self-tracing NSCs may also … for its lack of endogenous
repair and regeneration. For this … Inactivation of Rho by exoenzyme C3 transferase has been …

[HTML][HTML] The pathway from genes to gene therapy in glaucoma: a review of possibilities for using genes as glaucoma drugs

T Borrás - Asia-Pacific Journal of Ophthalmology, 2017 - Elsevier
… outflow pathway and lacked the secondary effects seen in … Inhibiting the same pathway by
delivering the exoenzyme C3 … these genes protected RGC loss in vivo. In one example, an …

[HTML][HTML] Lentiviral vectors for ocular gene therapy

Y Arsenijevic, A Berger, F Udry, C Kostic - Pharmaceutics, 2022 - mdpi.com
… One study focused on the Exoenzyme C3 transferase (C3), a Rho inhibitor that can modify …
was detected in vivo during 113 days with LV-GFP and to a lesser extent with the LV-C3-GFP (…

Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain

C O'Sullivan, GK Sheridan - …, 2016 - nottingham-repository.worktribe.com
… Please note that during the production process errors may be discovered which could affect
C3 exoenzyme (BoTXC3) or the antagonist Y-27632 (see Table 1), prior to peripheral nerve

[HTML][HTML] Caspases in the developing central nervous system: Apoptosis and beyond

TTM Nguyen, G Gillet, N Popgeorgiev - Frontiers in Cell and …, 2021 - frontiersin.org
… been well described in the peripheral nervous system (PNS). … In vivo, caspase-3 KO mice
display a lack of attention and … ” effects of caspase-3 activation suggests that nerve cells may be …

[PDF][PDF] Development of a Neuron Specific Non-Viral Delivery System for Rho-Kinase 2 Short Interfering RNA

KL O'Neill - 2019 - repositorio-aberto.up.pt
… valuable insight into the in vitro biological performance of the … inhibitors, namely exoenzyme
C3 (Clostridium botulinum) … , lack cell specificity and face the challenge of unwanted side …

Clostridium

IM Gohari, JF Prescott - Veterinary Microbiology, 2022 - Wiley Online Library
… toxins also affect the nervous system, and the severe depression, lack of … Both C2 toxin and
C3 exoenzyme are ADP- … diffuses via vascular channels or peripheral nerve trunks. The toxin …

The next‐generation therapies in ophthalmology for blindness worldwide

J Xu, CJ Zhang, JY Jiang, ZB Jin - Eye & ENT Research, 2024 - Wiley Online Library
… The Bowman's membrane lacks regenerative capacity, resulting in the … However, the
technology for in vitro cultivation of corneal … Lentiviral vector‐mediated expression of exoenzyme

Advances in chitosan and chitosan derivatives for biomedical applications in tissue engineering: An updated review

A Elizalde-Cárdenas, RM Ribas-Aparicio… - International Journal of …, 2024 - Elsevier
… polymer exerts antimicrobial effects on different microorganisms… However, ionically prepared
CS-based materials still lack … of action: endoenzymes and exoenzymes. Similarly, there are …