… According to a “two-hit” model for the molecular … differences in patient response to treatment
and chances of relapse. … Deletions of CDKN1B have been observed in pediatric ALL as well …

… Risk assessment and treatment selection were performed according to ALL IC-BFM … /B
loss and RB1 deletion was observed. IKZF1, MLLT3 and CD200/BTLA losses were associated …

… Deletion of CDKN2A/B was the most common lesion occurring in 38% of B-cell precursor
acute lymphoblastic leukemia … (eg, IKZF2, CD200/BTLA, TBL1XR1, NR3C2, ABL1, TP53, …

… ETV6::RUNX1 patients, we identified large genomic deletions and … B cell acute lymphoblastic
leukemia BCL11B … However, the patients in this thesis were treated mainly according to the …

… B cell precursor ALL in children, the presence of CD200/BTLA deletions was associated
with poor treatment outcome in patients treated according to the EORTC-CLG 58951 protocol, …

… were treated according to … deletion of CD200 and heterozygous deletion of BTLA, we
identified a case of ALL relapse with heterozygous deletion of CD200 and a homozygous deletion …

… It can be classified according to either immunophenotype or … are recurrent deletions in genes
controlling B-cell lineage … , disease recurrence and treatment failure in childhood ALL [112, …

… These patients are treated according to the EORTC-CLG … in BCP-ALL and CD200/BTLA
deletions do not affect prognosis … treatment evaluation of B-cell acute lymphoblastic leukemia. …

… cytogenetically visible deletions and submicroscopic copy … the therapeutic regimen used was
according to the AIEOP-BFM… , particularly when treated with a modern treatment regime that …

… 80% of ALL cases derived from B-cell precursors (BCP-ALL) [1]… We divided tumours according
to CTCF (mutated/deleted) … histone gene cluster 1 deletions and CTCF alterations share a …