[HTML][HTML] Myelin-specific CD8+ T cells exacerbate brain inflammation in CNS autoimmunity
CA Wagner, PJ Roqué, TR Mileur… - The Journal of …, 2020 - Am Soc Clin Investig
… activated CD8 + T cells from tissues (36), we induced disease by transferring CD4 + T cells
… observed when 8.8 CD8 + T cells infiltrate the brain influenced the inflammatory infiltrate, we …
… observed when 8.8 CD8 + T cells infiltrate the brain influenced the inflammatory infiltrate, we …
Encephalitogenic and regulatory CD8 T cells in multiple sclerosis and its animal models
TE Mockus, A Munie, JR Atkinson… - The Journal of …, 2021 - journals.aai.org
… Although cytotoxic CD8 T cells exhibit gliotoxic and neurotoxic properties … inflammatory
demyelination, alternative CD8 T cell subsets have been identified that possess anti-inflammatory …
demyelination, alternative CD8 T cell subsets have been identified that possess anti-inflammatory …
Longitudinal imaging of T cells and inflammatory demyelination in a preclinical model of multiple sclerosis using 18F-FAraG PET and MRI
C Guglielmetti, J Levi, TL Huynh, B Tiret… - Journal of Nuclear …, 2022 - Soc Nuclear Med
… T cells into the CNS (16). Our findings showed that MRI allowed the detection of inflammatory
demyelination independently of T cell … lesion stratification by informing on T cell load, thus …
demyelination independently of T cell … lesion stratification by informing on T cell load, thus …
CD8+ T cell subpopulations and pro‐inflammatory cytokines in neuromyelitis optica spectrum disorder
Z Shi, Y Qiu, Z Zhao, D Wen, H Chen… - Annals of Clinical …, 2021 - Wiley Online Library
… T cells were considered as documented players in participating the progress of inflammatory
demyelinating disease … naïve CD8 + T cells and decreased effector/memory CD8 + T cells …
demyelinating disease … naïve CD8 + T cells and decreased effector/memory CD8 + T cells …
Cuprizone‐induced demyelination triggers a CD8‐pronounced T cell recruitment
… Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS), leading to irreversible neuronal damage and, as a consequence, clinical disability…
system (CNS), leading to irreversible neuronal damage and, as a consequence, clinical disability…
Inflammatory demyelinating diseases of the central nervous system
R Höftberger, H Lassmann - Handbook of clinical neurology, 2018 - Elsevier
… that cytotoxic T cells may in part selectively mediate the inflammatory … CD8 + cells (Durrenberger
et al., 2012). Interestingly, lower numbers of circulating regulatory T cells (FoxP3 +, CD8 …
et al., 2012). Interestingly, lower numbers of circulating regulatory T cells (FoxP3 +, CD8 …
[HTML][HTML] Expanding role of T cells in human autoimmune diseases of the central nervous system
… from a predominantly CD4 + T cell field to include CD8 + cytotoxic T cells as a novel effector
… is a monophasic inflammatory demyelinating disease predominantly affecting children. It …
… is a monophasic inflammatory demyelinating disease predominantly affecting children. It …
The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells
J Machado-Santos, E Saji, AR Tröscher, M Paunovic… - Brain, 2018 - academic.oup.com
… Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination
… In this study, we performed an in-depth phenotypic characterization of T and B cell infiltrates …
… In this study, we performed an in-depth phenotypic characterization of T and B cell infiltrates …
[HTML][HTML] Therapeutic intervention in relapsing autoimmune demyelinating disease through induction of myelin-specific regulatory CD8 T cell responses
AA Brate, AW Boyden, FR Itani, LL Pewe… - Journal of translational …, 2019 - Elsevier
… CD8 T cells in vivo, we show that LM infection induced disease suppressive CD8 T cells
that protected and treated PLP 178-191 disease. Importantly, a combination of PLP 178-191 -…
that protected and treated PLP 178-191 disease. Importantly, a combination of PLP 178-191 -…
[HTML][HTML] Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
…, L Herbst, M Alexis, J Karnell, T Davidson… - Nature …, 2019 - nature.com
… inflammatory demyelinating mouse model. Here we report that OPC differentiation is inhibited
by both effector T cells … antigen to cytotoxic CD8 T cells, resulting in OPC death. In human …
by both effector T cells … antigen to cytotoxic CD8 T cells, resulting in OPC death. In human …