… pathway causing cell cycle proliferation, signaling mitochondria to … like activation of p21 and
termination of cell cycle are lost. … and COX-2 inhibitors is viable since PPAR-γ agonist induce …

… -specific structures and signal transduction-associated … that COX-2 inhibitors sensitize lung
cancer cells to X-rays, … the expression of cell cycle inhibitory proteins, including p21/waf1 and …

… -2 mRNA in the liver cancer cells induced by HGF, therefore … , the regulation by COX-2 on
p53 will also regulate p21 [27]. … ) might inhibit the lung cancer through their COX-2 inhibition …

… reduced COX‑2 expression, a marked increase in Cip1/p21 … The signal was visualized using
an ECL detection system. … ± SEM of cells in each phase in three independent experiments. *…

… on COX-2, and the other mechanism acts through a signaling pathway independent of
COX-2. … -initiated cell cycle arrest at the G0/G1 phase via the activation of p21 and subsequent …

… angiogenesis through MMP-9 and COX-2 inhibition in human … These results were obtained
from three independent … determined by normalizing the 3C PCR signal relative to that of the …

… Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) … of p53 and its downstream
target p21 in the combined group, … on how metformin inhibits ERK signaling without causing …

… in many tumor types including lung cancer, and COX-2 … signaling inhibition was an important
step in the induction of … or inducing of p27 and p21 expression, resulting in cell cycle arrest […

… The mouse Lewis lung cancer (LLC) cell line was kindly … anti-COX-2 antibody (1:100, #12282;
Cell Signaling Technology) … tissues expressed less p21 in adult WT mice than in COX-2 …

… the fibroblast senescence via P53 signaling pathways, and … of data from at least three
separate experiments is shown. ###… , P21, P16 INK4a , and α-SMA were increased in the COX-2 …