CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
Y Zohar, G Wildbaum, R Novak… - The Journal of …, 2018 - Am Soc Clin Investig
A single G protein–coupled receptor (GPCR) can activate multiple signaling cascades
based on the binding of different ligands. The biological relevance of this feature in immune
regulation has not been evaluated. The chemokine-binding GPCR CXCR3 is preferentially
expressed on CD4+ T cells, and canonically binds 3 structurally related chemokines:
CXCL9, CXCL10, and CXCL11. Here we have shown that CXCL10/CXCR3 interactions
drive effector Th1 polarization via STAT1, STAT4, and STAT5 phosphorylation, while …
based on the binding of different ligands. The biological relevance of this feature in immune
regulation has not been evaluated. The chemokine-binding GPCR CXCR3 is preferentially
expressed on CD4+ T cells, and canonically binds 3 structurally related chemokines:
CXCL9, CXCL10, and CXCL11. Here we have shown that CXCL10/CXCR3 interactions
drive effector Th1 polarization via STAT1, STAT4, and STAT5 phosphorylation, while …
CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
Y Zohar, G Wildbaum, R Novak… - The Journal of …, 2017 - Am Soc Clin Investig
A single G protein–coupled receptor (GPCR) can activate multiple signaling cascades
based on the binding of different ligands. The biological relevance of this feature in immune
regulation has not been evaluated. The chemokine-binding GPCR CXCR3 is preferentially
expressed on CD4+ T cells, and canonically binds 3 structurally related chemokines:
CXCL9, CXCL10, and CXCL11. Here we have shown that CXCL10/CXCR3 interactions
drive effector Th1 polarization via STAT1, STAT4, and STAT5 phosphorylation, while …
based on the binding of different ligands. The biological relevance of this feature in immune
regulation has not been evaluated. The chemokine-binding GPCR CXCR3 is preferentially
expressed on CD4+ T cells, and canonically binds 3 structurally related chemokines:
CXCL9, CXCL10, and CXCL11. Here we have shown that CXCL10/CXCR3 interactions
drive effector Th1 polarization via STAT1, STAT4, and STAT5 phosphorylation, while …
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