… reduced virulence as confirmed by the 50% lethal dose (LD 50 ) in orally infected mice.
C50336ΔsptP also showed decreased … past 20 years, Salmonella enterica serovar Enteritidis (S. …

… of yjeK gene attenuated the virulence of Salmonella enterica serovar Typhimurium without
losing … Besides, we also found that the ΔyjeK mutant decreased the expression levels of SPI-2 …

… using a live-attenuated Salmonella enterica serovar Typhi strain in … , while over-attenuated
candidate vaccine strains have not … In this study, low doses of attenuated organisms were …

… We hypothesized that the deletion of htrA would not over-attenuate CVD 1921 but reduce its
reactogenicity while maintaining its immunogenicity and protective efficacy. We investigated …

… were not ideal vaccine candidates. With the genomic information in hand, we engineered a
live attenuated S. Paratyphi … We observed no vaccine efficacy against low (LD 50 of ∼100) S. …

… of Salmonella enterica serovar Typhi and Salmonella enterica serovar Typhimurium, focusing
on human Salmonella infections. … Typhimurium vaccine received a 3 log unit lower dose of …

… However, an inactivated vaccine has the disadvantages of low immunogenicity, weak …
Pullorum constructed by genetic engineering has been evaluated as a candidate vaccine for S. …

… Typhimurium vaccine candidate CVD 1921 (I77 ΔguaBA ΔclpP… Here we describe a
further attenuated vaccine candidate … under the age of 5 years living in lower- and lower-to-middle-…

… humans which all target Salmonella enterica serovar Typhi. … acid resistance and reduce the
potential for transmission. … resistance of live attenuated Salmonella candidate vaccines. The …

… have constructed three vaccine candidates by deleting four … strains were attenuated and
had significantly reduced ability … by the three live attenuated vaccine candidates tested in this …