An overview of apoptosis assays detecting DNA fragmentation

P Majtnerová, T Roušar - Molecular biology reports, 2018 - Springer
… The morphological changes during apoptosis include … (nucleus fragmentation) followed
by DNA fragmentation. The … is cleaved by activated caspase 3 (a-caspase 3), which is …

Caspase-3 mediated cell death in the normal development of the mammalian cerebellum

L Lossi, C Castagna, A Merighi - International journal of molecular …, 2018 - mdpi.com
Caspase-3 is a key enzyme in the execution of apoptosis. The … that these neurons underwent
DNA fragmentation in the EGL … the onset of morphological alterations and reduction in the …

GSH depletion, mitochondrial membrane breakdown, caspase-3/7 activation and DNA fragmentation in U87MG glioblastoma cells: New insight into the mechanism of …

A Beberok, Z Rzepka, M Respondek, J Rok… - European Journal of …, 2018 - Elsevier
… as shown by externalization of phosphatidylserine, caspase-3/7 activation, S and …
morphological changes induction and DNA fragmentation. The mechanism of apoptosis was related

Induction of apoptosis by chalepin through phosphatidylserine externalisations and DNA fragmentation in breast cancer cells (MCF7)

MI Fakai, SN Abd Malek, SA Karsani - Life sciences, 2019 - Elsevier
… Various features including morphological changes … , activation of caspases and DNA
fragmentation; which has been found to … including caspase-3, 8 and 9 play a vital role in apoptosis

Platinum nanoparticles induced genotoxicity and apoptotic activity in human normal and cancer hepatic cells via oxidative stress‐mediated Bax/Bcl‐2 and caspase3 …

MHA Almarzoug, D Ali, S Alarifi… - Environmental …, 2020 - Wiley Online Library
… Determination of morphological changes of cells, chromosome condensation, mitochondrial
… of apoptotic genes by real-time PCR (RT-PCR). The percentage of DNA fragmentation was …

[HTML][HTML] Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation

A Jafri, S Siddiqui, J Rais, MS Ahmad, S Kumar… - Excli Journal, 2019 - ncbi.nlm.nih.gov
apoptosis and loss of mitochondrial membrane potential (MMP). DNA fragmentation, cell
cycle kinetics, caspase-3 … Cellular morphological alterations were observed in HeLa cells at …

Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis

E Eskandari, CJ Eaves - Journal of Cell Biology, 2022 - rupress.org
… function of caspase-3 required for its late role in apoptosis, and, … morphological changes
in apoptotic cells. For example, … condensation and DNA fragmentation by cleaving DNA at …

Role of caspase-3-mediated apoptosis in chronic caspase-3-cleaved tau accumulation and blood–brain barrier damage in the corpus callosum after traumatic brain …

OY Glushakova, AO Glushakov… - Journal of …, 2018 - liebertpub.com
changes following TBI in cleaved-caspase-3 and caspase-3-… cellular markers potentially
associated with inflammation and … caspase-3 activation and associated morphological changes

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

C Rogers, T Fernandes-Alnemri, L Mayes… - Nature …, 2017 - nature.com
… executioner caspases (caspase-3, 6 and 7), which target >600 substrates to orchestrate
morphological changes associated with apoptosis 14 . At the terminal stage of apoptosis, cells …

Cell-in-cell death is not restricted by caspase-3 deficiency in MCF-7 cells

S Wang, M He, L Li, Z Liang, Z Zou… - Journal of breast …, 2016 - synapse.koreamed.org
… Results: Our results confirmed that MCF-7 cells are caspase-3 deficient with a … Caspase-3
is required for DNA fragmentation and morphological changes associated with apoptosis