Multifaceted Regulation of Neuronal L-Type Ca2+ Channels by the N-Terminal Domain: from CaMKII Targeting to Nuclear Signaling

X Wang - 2018 - ir.vanderbilt.edu
… on neuronal L-type Ca2+ channels, namely CaV1.2 and CaV1.3. … CaV1.2 and TRPV1
channels exist in the same macromolecular complex with AKAP150 in wild-type sensory neurons

Key roles of CACNA1C/Cav1. 2 and CALB1/calbindin in prefrontal neurons altered in cognitive disorders

D Datta, S Yang, MKP Joyce, E Woo… - JAMA …, 2024 - jamanetwork.com
… The risk of mental disorders is consistently associated with variants inCACNA1C(L-type
calcium channel Cav1.2) but it is not known why these channels are critical to cognition, and …

[HTML][HTML] Cav2. 3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease

J Benkert, S Hess, S Roy, D Beccano-Kelly… - Nature …, 2019 - nature.com
L-type voltage-gated Ca 2+ channels in the brain and in SN dopaminergic neurons in particular
are built from Cav1.2 and Cav1.3 … -1 within the complex Ca 2+ signaling and PARK gene …

L-type Ca2+ channel–mediated Ca2+ influx adjusts neuronal mitochondrial function to physiological and pathophysiological conditions

M Hotka, M Cagalinec, K Hilber, L Hool, S Boehm… - … signaling, 2020 - science.org
… Our findings indicate a complex role of LTCC-mediated Ca 2+ influx in the tuning and
maintenance of mitochondrial function. Therefore, the use of LTCC inhibitors to protect …

[HTML][HTML] Calcium Channels and Calcium-Binding Proteins

S Mochida - International Journal of Molecular Sciences, 2023 - mdpi.com
… is composed into signaling complexes, with their signaling capacity … ), neuron changes in the
density of dendritic L-type VGCCs … Ca 2+ influx through Cav1.2 channels is regulated by the …

Altered function of neuronal L-type calcium channels in ageing and neuroinflammation: Implications in age-related synaptic dysfunction and cognitive decline

S Navakkode, C Liu, TW Soong - Ageing Research Reviews, 2018 - Elsevier
Neurons express two sub-types of neuronal LTCCs that are encoded by Cav1.2 and Cav1.3
… .3 immunolabelling is detected in the cell bodies of CA1, CA2 and CA3 pyramidal neurons

Activity of T-type calcium channels is independent of CRMP2 in sensory neurons

S Cai, Z Shan, Z Zhang, A Moutal, R Khanna - Channels, 2019 - Taylor & Francis
… 20] likely though a motif in the C-terminus in the CaV1.2 … in DRG neurons T-type calcium
channels can recover from … of sensory neurons expressing T-type calcium channels. Thus, we …

[HTML][HTML] CaV1.3 L-Type Calcium Channels Increase the Vulnerability of Substantia Nigra Dopaminergic Neurons in MPTP Mouse Model of Parkinson's Disease

A Verma, V Ravindranath - Frontiers in Aging Neuroscience, 2020 - frontiersin.org
… DA neurons of SNpc and VTA are autonomous pacemakers but pacemaking in … by calcium
influx through L-type calcium channel, Ca V 1.3 contributing to increased intracellular calcium

[HTML][HTML] Presynaptic calcium channels

S Mochida - International Journal of Molecular Sciences, 2019 - mdpi.com
complex, and the γ subunit having four transmembrane segments. In contrast, brain neuron
Ca V 2 channels … voltage-gated Ca 2+ channel Cav1.1 complex at a nominal resolution of 4.2 …

The relevance of L-type calcium channel gating properties to cardiac arrhythmia and differential modulation of L-type CaV channels by the α2δ-1 auxiliary subunit

F Steccanella - 2019 - iris.univr.it
L-type Ca2+ channels: the cardiac voltage-gated Ca2+ channel CaV1.2 and the skeletal
CaV1.1… CaV1 channels exist as multimeric protein complexes consisting of the pore-forming α1 …